( Independent Japanese study demonstra...)Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study,Health

BASEL, Switzerland, April 27, 2007 - New findings from the independent Jikei Heart Study, published today in The Lancet[1], show that adding the blood pressure lowering medication Diovan® to conventional therapy produced a dramatic 39% reduction in cardiovascular events and a 40% reduction in stroke.

The superior benefits reported with Diovan led to an early termination of the study, which involved more than 3,000 Japanese patients.

In addition to its impact on overall cardiovascular events and stroke, Diovan demonstrated relative reductions of 65% in angina pectoris (recurring acute chest pain), 46% in heart failure and 81% in aortic dissection (separation of the wall layers in the body's main artery) compared to other treatment groups1. According to the investigators, these benefits cannot be explained by a difference in blood pressure alone. There were few adverse events (2.5% overall) with no significant difference in tolerability between the groups.

"The results of this trial carry an important clinical message for physicians across the globe who are trying to protect patients from debilitating complications such as stroke," said Gordon McInnes, MD, Professor of Medicine at the Western Infirmary in Glasgow, Scotland. "Jikei Heart tells us that adding Diovan to usual treatment regimens can offer substantial long-term protection."

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