Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study
- Independent Japanese study demonstrates dramatic
benefits of adding Diovan to conventional therapy
- Study halted early due to superior outcomes for
Switzerland, April 27, 2007 - New findings from the independent
Jikei Heart Study, published today in The Lancet, show that
adding the blood pressure lowering medication Diovan® to
conventional therapy produced a dramatic 39% reduction in
cardiovascular events and a 40% reduction in stroke.
The superior benefits reported
with Diovan led to an early termination of the study, which
involved more than 3,000 Japanese patients.
In addition to its impact on
overall cardiovascular events and stroke, Diovan demonstrated
relative reductions of 65% in angina pectoris (recurring acute
chest pain), 46% in heart failure and 81% in aortic dissection
(separation of the wall layers in the body's main artery) compared
to other treatment groups1. According to the investigators, these
benefits cannot be explained by a difference in blood pressure
alone. There were few adverse events (2.5% overall) with no
significant difference in tolerability between the groups.
"The results of this trial carry
an important clinical message for physicians across the globe who
are trying to protect patients from debilitating complications such
as stroke," said Gordon McInnes, MD, Professor of Medicine at the
Western Infirmary in Glasgow, Scotland. "Jikei Heart tells us that
adding Diovan to usual treatment regimens can offer substantial
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