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Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study

t on overall cardiovascular events and stroke, Diovan demonstrated relative reductions of 65% in angina pectoris (recurring acute chest pain), 47% in heart failure and 81% in aortic dissection (separation of the wall layers in the body’s main artery) compared to other treatment groups1. According to the investigators, these benefits cannot be explained by a difference in blood pressure alone. There were few adverse events (2.5% overall) with no significant difference in tolerability between the groups.

“The results of this trial carry an important clinical message for physicians across the globe who are trying to protect patients from debilitating complications such as stroke,” said Gordon McInnes, MD, Professor of Medicine at the Western Infirmary in Glasgow, Scotland. “Jikei Heart tells us that adding Diovan to usual treatment regimens can offer substantial long-term protection.”

The Jikei Heart Study is the first controlled trial to assess the cardiovascular benefits of adding the angiotensin receptor blocker (ARB) Diovan to conventional non-ARB therapy, compared to non-ARB therapy alone, in a large Japanese population. Key events evaluated as part of the primary endpoint included heart attack, stroke and hospitalization for heart failure or angina pectoris.

The study was conceived, designed, and conducted by an investigat
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