Navigation Links
Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control


Beth Wegerbauer
Contributing Editor

According to the American Diabetes Association, the total annual economic cost of diabetes in 2002 was estimated to be $132 billion, or one out of every 10 health care dollars spent in the United States. A chronic disease with no cure, diabetes is a group of diseases (including Type 1, Type 2, and gestational) marked by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. Nearly 20 million Americans have diabetes and nearly one-third of them don't even know it.

To combat this problem, the U.S. Department of Health and Human Services launched the Diabetes Detection Initiative to find this undiagnosed population through increased testing. Early diagnosis means that early steps can be taken to manage the disease and to prevent or delay complications.

The American Diabetes Association (ADA) recommends the hemoglobin A1C test, or HbA1c, as the best way to determine a patient's blood glucose control over the past 2-3 months. Specifically, the test measures the concentration of glycosylated hemoglobin. A1C levels are measured upon diagnosis, and, depending on a patient's type of diabetes, how well it is controlled, and his or her health-care provider, levels may be measured two to four times per year. Determining blood glucose control through this laboratory testing gives health-care providers the data they need to monitor the disease and to recommend appropriate treatment. Results from a major diabetes study, the Diabetes Control and Complications Trial (DCCT), confirm this test's importance. The study showed that lowering the HbA1c number can potentially reduce the development of complications and that lowering HbA1c levels by any amount improves a person's chances of staying healthy.

All HbA1c tests are not the same, but there is an ongoing international effort to standardize them by organizations like the National Glycoh emoglobin Standardization Program (NGSP) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). In fact, nearly all laboratories in the United States use NGSP-certified methods. This helps to ensure that a test performed by a laboratory professional in Texas would show the same result as one performed in Pennsylvania. Other recent developments include using the name "A1C" as the test's official name and adopting a reference method suggested by IFCC as the international standard. Such a method requires additional education for both health-care providers and patients because the numbers reported as test results will differ from those currently in use. Eventually, standardization will improve the testing's consistency, but, for now, current methods and result reporting will still be used.

The HbA1c test is usually done in a health-care provider's office, where a small blood sample is drawn. A laboratory tests the sample and then gives the results to the patient's health-care provider. A study published in Diabetes Care (Cagliero E, Levina EV, Nathan DM. Immediate feedback of HbA1c levels improves glycemic control in type 1 and insulin-treated type 2 diabetic patients. Diabetes Care 1999; 22:1785-1789) tried to determine if accurate and reliable HbA1c results could be obtained at the time of an office visit by using bench top analyzers. The authors tested the hypothesis that immediately available results could improve glycemic control by changing either physician or patient behavior or both. They concluded that immediate feedback based on HbA1c results at the time of patient encounters resulted in a significant improvement of glycemic control at the 6-month follow-up and persisted for the 12-month study.

Bio-Rad Laboratories, Hercules, CA, has expanded the testing capacity of its D-10 Hemoglobin Testing System with the addition of the D-10 Rack Loader. The Rack Loader increases the system's capacity from 10 to 50 whole blood samples, allowing users to load more samples at one time (and continuously) during a run. The fully automated system combines diabetes monitoring and -thalassemia testing on one platform, offering 3-minute HbA1c program or 6.5-minute HbA2/F/A1c dual program options.

The G7 manufactured by Tosoh Bioscience, Inc., San Francisco, CA, is a fully automated glycohemoglobin analyzer that also offers HbA1c and -thalassemia testing in one platform. Stable HbA1c results are available in 2.2 minutes and -thalassemia results in less than 8 minutes, with quantification of HbF and HbA2. Both systems offer additional features like touch-screen operation and a compact size to conserve counter space.

The circulation of autoantibodies against antigens like insulin provides early markers of autoimmune disease activity. Measurement of these markers has been shown to be valuable in helping health-care providers diagnose and manage their diabetes patients. KRONUS, Inc., Boise, ID, offers a variety of ELISA and RIA kits for the quantitative determination of autoantibodies in serum, like the recently FDA-approved glutamic acid decarboxylase (GAD) Autoantibody RIA Test Kit. Antibodies to GAD have been shown to be the most sensitive single marker for identifying people at risk of developing diabetes.

Available HbA1c analyzers that produce results within minutes are important tools in the detection and management of diabetes. When results are reported during the patient's visit, health-care providers can offer instant feedback and make necessary treatment adjustments. Immediate results mean immediate intervention, resulting in greater diabetes control for both health-care providers and patients.

Beth Wegerbauer is a medical writer and editor with 12 years of experience covering the clinical laboratory field.
'"/>




Related medicine technology :

1. Point of Care Cardiac Analyzers Yield Rapid Cardiac Marker Results
2. Tight Glycemic Control in the ICU
3. Controlling the Spread of Healthcare Associated Methicillin Resistant Staphylococcus aureus Requires Active Surveillance
4. New Quality Control Systems for Every Laboratory Application
5. Optimizing Quality Control Data Management

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... an upgrade. There are many medical recorders on the market but none like this. ... HD  offers unparalleled connectivity and functionality.  Ampronix  is a renowned authorized reseller of the ... Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
(Date:5/4/2016)... New Jersey , May 4, 2016 ... its successful completion of an alternative public offering (APO). ... wholly owned operating company, Valeritas, Inc. and a private ... common stock at $5.00 per share. Under ... on May 3, 2016, Valeritas Holdings, Inc. will trade ...
(Date:5/4/2016)... 2016 Research and ... Acute lymphocytic Leukemia Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Market and Competitive Landscape Highlights 2016, provides ... products, Acute Lymphocytic Leukemia epidemiology, Acute Lymphocytic ...
Breaking Medicine Technology:
(Date:5/5/2016)... ... 2016 , ... Derrin Doty Group has unveiled the latest charity campaign in ... west of Seattle. The insurance provider’s caring team has been so moved by the ... to complications from the flu, that they have decided to extend their original campaign. ...
(Date:5/5/2016)... Portland, Oregon (PRWEB) , ... May 05, 2016 ... ... the Student American Chiropractic Association (SACA) is slated to host the 2016 National ... chance for all current SACA national officers and chapter officers to come together ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... Vitenas Cosmetic ... Healthcare Design Awards, presented by the American Institute of Architects and the Academy of ... by the renowned Perkins+Will and Harrell Architects, opened to patients in October of 2014. ...
(Date:5/5/2016)... ... May 05, 2016 , ... Dr. Benjamin Stong of Kalos Facial ... treatment. Dr. Stong is double board certified and the only facial plastic surgeon ... of hair loss. Non-surgical therapies such as stem cells can be used to provide ...
(Date:5/5/2016)... ... ... In honor of National Nurses Week 2016, Aya Healthcare , the ... thank a nurse who's made a difference in their life. From Friday, May 6 ... of San Diego/Imperial Counties (up to $10,000) every time someone tells them via social ...
Breaking Medicine News(10 mins):