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Daytrana (methylphenidate transdermal system) Provides Significant,Effectiveness in ADHD Symptom Relief in Both Boys and Girls

Shire plc's filings with the Securities and Exchange Commission, particularly Shire plc's Annual Report on Form 10-K for the year ended December 31, 2006.

Daytrana(TM) is a trademark of Shire Pharmaceuticals Ireland Limited.

CONTACT: Marion E. Glick, +1-212-601-8273, +1-917-301-4206 on site at APA,, or Jennifer Anello, +1-212-601-8132,+1-203-470-0836 on site at APA, , both ofPorter Novelli for Shire marion.glick@porternovelli.com jennifer.anello@porternovelli.com

Web site: http://www.shire.com/

Ticker Symbol: (NASDAQ-NMS:SHPGY),(Toronto:SHQ.)

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