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Data supporting three Antisoma programmes presented at AACR

LONDON, and LOS ANGELES, 16 April 2007- Antisoma announces that preclinical data supporting three of its drugs are presented this week at the Annual Meeting of the American Association of Cancer Research (AACR).

AS1404-Avastin-paclitaxel triple combination highly effective Antisoma's scientists have for the first time evaluated a triple combination of the Company's vascular disrupting agent, AS1404, the anti-angiogenic Avastin and the chemotherapy drug paclitaxel. The triple combination had powerful and synergistic (more than additive) anti-tumour effects in a human lung cancer xenograft model. Moreover, addition of Avastin and paclitaxel to AS1404 did not increase toxicity.

These observations build on previous xenograft findings showing a synergistic effect with an AS1404-paclitaxel combination. That effect translated into a substantial survival benefit in a phase II trial in non-small cell lung cancer. Preparations are being made for a pivotal phase III trial combining AS1404 with chemotherapy in lung cancer. The market opportunity in this setting is large, and would be further extended if AS1404 also proved effective when added to an Avastin-chemotherapy combination.

Synergistic effect of AS1404 combined with Erbitux In a second combination study, AS1404 showed synergistic anti-tumour effects with Erbitux in a lung cancer model. These findings, together with the Avastin data, show that AS1404 has potential in combination with newer, targeted therapies as well as longer established treatments such as chemotherapies.

Broad potential of AS1411 alone and in combination New data show that the aptamer drug AS1411 kills cells from a wide variety of cancer cell lines. These include lines representing the four most common cancers: lung, breast, prostate and colorectal; as well as renal, gastric, pancreatic, melanoma, glioblastoma and certain blood cancer lines. Doses lethal to cancer cells
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