( ference at the end ofthe 12 weeks sign...)Data Suggest Cymbalta Reduced Severity of Night Pain in Patients,with Diabetic Nerve Pain,Health

Of greatest interest is the fact that for the first time, a clear correlation between reduction in average daily pain and average night pain and reduction in pain sleep interference was demonstrated in a population that was not depressed, did not experience treatment-emergent somnolence and was not on medications commonly associated with sedation. Other published studies of the relationship between pain and sleep interference have been confounded by at least one of those conditions.

"Patients with diabetic nerve pain often complain of being awoken, or having difficulty falling asleep because of pain, and it is difficult for physicians to know whether sleep problems are the cause or effect of pain," said David Fishbain, M.D., distinguished professor of psychiatry, adjunct professor of neurological surgery and anesthesiology at the University of Miami, and lead study author. "This new analysis is important because it suggests that interference with sleep generally improves if nighttime pain improves."

In this analysis, the most common adverse events experienced in the entire patient population as a whole were nausea, somnolence, dizziness, constipation, hyperhidrosis, dry mouth and decreased appetite. The median duration of nausea, somnolence and dizziness in Cymbalta-treated patients was six days, 14 days and five days, respectively, with the majority of patients who experienced these adverse events rating them as mild to moderate in severity. The overall discontinuation rate for patients on Cymbalta was 14 percent, while the overall discontinuation rate for patients on placebo was 7 percent. The most common adverse event cited as a reason for discontinuation was nausea (4 percent), followed by so
'"/>