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Data Suggest Cymbalta Improved Functioning in Patients with,Generalized Anxiety Disorder

Relationship Between Ability to Function and Treatment of Anxious and Painful Physical Symptoms Studied

INDIANAPOLIS, May 21, 2007 /PRNewswire-FirstCall/ -- Data suggest that patients with generalized anxiety disorder (GAD) treated with Cymbalta(R) (duloxetine HCl) experienced improved ability to perform everyday activities at home, work and in social situations compared to sugar pill. These improvements in global functioning were the result of improvements in anxious symptoms, as well as through an improvement in the painful physical symptoms that can be associated with the condition. The results of these data from two GAD registration studies of more than 840 patients were presented today at a major medical meeting of psychiatrists.

These analyses focused on the relationship between global functional impairment and the treatment of anxious and painful physical symptoms in patients with GAD. Improvement in global functioning was measured by the Sheehan Disability Scale (SDS), which assesses the extent emotional symptoms disrupt ability to perform everyday activities at work, home and in social situations.

In one of the two studies, patients treated with 60 mg and 120 mg once daily of Cymbalta experienced statistically significant improvements compared to those treated with a sugar pill (defined by mean change on SDS, 7.76 and 7.04 vs. 3.83). In the second study, patients treated with 60-120 mg once daily of Cymbalta experienced statistically significant improvements compared to those treated with a sugar pill (defined by mean change on SDS 5.78 vs. 3.11). In the pooled analysis, among Cymbalta-treated patients, 48 percent of improvement in global functioning was from improvements in psychic anxiety, while 9 percent was from improvements in painful physical symptoms and 7 percent was from improvements in somatic anxiety associated with GAD.

Since GAD presents with a variety of symptoms, it
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