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Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor,Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

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Using CLIMB, researchers created a model of Axl kinase to screen a large virtual library of chemical structures from which five chemical lead scaffolds were selected. Structural modifications improved biochemical and cell-based potency that resulted in compounds that exhibit sensitization to apoptosis and down regulation of Axl-dependent signaling pathways. Inhibitor SGI-AXL-277, a pyrrolopyrimidine, demonstrated low micromolar activity against the Axl enzyme and in cell proliferation assays. Lead optimization toward the identification of a clinical candidate is ongoing.

Abstract No. 2387

Discovery and characterization of small molecule inhibitors for Jak2

Janus kinases (JAKs) are critical to a number of intracellular signaling pathways. Failure of Jak2 regulation or mutations that activate Jak2 expression are implicated in leukemias, lymphomas and various solid tumors. Utilizing CLIMB, researchers used a Jak2 crystal structure to build several models that were made into a substrate for screening a large, virtual small molecule library. This process generated a subset of leads based on calculated binding energies. These leads were then screened in silico to determine "druggable" candidates. Cell-based activity was determined in HEL, K562, MO7 and other human cancer cell lines.

Abstract No. 2229

Zebrafish as a model mechanistic screen for small molecule inhibitors of DNMT1

Data suggest that the zebrafish model offers a fast and reliable method to identify small molecule inhibitors of DNA methyltransferase (DNMT). DNMT1 is considered to be the DNA methyltransferase enzyme mainly responsible for maintaining abnormal promoter methylation in various cancer types. Zebrafish embryos are a viable model for cancer drug research because of their close similarity to humans and their fast and easily visible development. Small molecules that inhibit DNMT1 should produce terminal differentiation abnormalities of the gut tube, retina
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