Navigation Links
Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor,Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

al of MP470," said Dr. James S. Manuso, SuperGen's Chairman, President and Chief Executive Officer. "Our products and programs were highlighted in seven posters and a mini-symposium. The data presented brings to light important new aspects of our late-stage preclinical compounds and also validates CLIMB as a rapid and powerful process for the identification of a broad range of potent small molecule inhibitors."

Abstract No. 4028

MP470, a potent suppressor of Rad51, improves response to platinum-based anticancer agents

Rad51 is an important protein involved in resistance to cytotoxic/DNA damaging therapies that are commonly used to treat tumors. It acts to repair the double stranded DNA breaks that are caused by therapies, thus limiting their efficacy and increasing dosage requirements. Data indicate that SuperGen's novel compound, MP470, blocks the induction of Rad51 by anticancer platinum agents. MP470, in combination with carboplatin and paclitaxel in small cell and non-small cell lung cancer lines, showed a significant improvement in tumor response over the carboplatin/paclitaxel treatments alone. A combination therapy regimen that includes MP470 in addition to a platinum-based cytotoxic agent could reduce dosage requirements and widen the therapeutic window.

Abstract No. 1540

Hydrochloride salt of MP470, a potent suppressor of Rad51, improves bioavailability and tolerability

Results from this study suggest that the hydrochloride salt of MP470 (MP470.HCl) could lead to improved safety and tolerability of the compound. Data indicate that MP470.HCl exhibits a several-fold improvement in oral bioavailability when compared to the free base. The compound had a wide therapeutic window in rat and dog models. Additionally, no apparent serious toxicities in the expected therapeutic dose range were observed.

Abstract No. 2380

Discovery and characterization of a series of Axl kinase inhibitors using the CLIMB process'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Brutons Tyrosine Kinase Inhibitors
2. AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer
3. Pharmacyclics Announces Presentations on Its Novel and Selective HDAC and Brutons Tyrosine Kinase Inhibitor Compounds
4. EntreMeds Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models
5. Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor Data Showing Broad Anti-Tumor Activity, Dosing Flexibility
6. NIEHS Researchers Identify Enzyme Critical in DNA Replication
7. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
8. Critical Therapeutics Announces the Publication of Data for ZyfloCR (Zileuton) Extended-Release Tablets in the Journal of Asthma
9. New Critical Path Report Highlights Research Needed to Foster Generic Drug Development
10. Critical Therapeutics Announces the Publication of New Preclincial HMGB1 Data in Nature Immunology
11. MIV Therapeutics Announces Pivotal Test Results Further Validating Company Stent Coatings Meet Critical FDA Fatigue Guidelines
Post Your Comments:
(Date:8/3/2015)... , Aug. 3, 2015 Biosensors International ... SP; Reuters: BIOS.SI; SGX: B20), a developer, manufacturer ... financial results for its first fiscal quarter ended ... Quarter Highlights and Recent Developments: ... improving its cost structure, driven by lower operating ...
(Date:8/3/2015)... 3, 2015 /OFF HOLD ... LLC, PIV757417 The following release: "Biotech Advancements Coupled ... Products & Treatments for Critical-Care Patients With Severe ... 3 Aug 2015 12:30 GMT Cooperative ... surgical research and top-tier universities for identifying biotech ...
(Date:8/3/2015)...  Array BioPharma Inc. (NASDAQ: ARRY ) ... full year of its fiscal year ended June ... of Array, noted, "Binimetinib and encorafenib, two innovative ... for regulatory submissions in 2016. Additional data shared ... colorectal cancer further validate the value of these ...
Breaking Medicine Technology:Biosensors Reports Financial Results for the First Quarter of Fiscal Year 2016 2Biosensors Reports Financial Results for the First Quarter of Fiscal Year 2016 3Biosensors Reports Financial Results for the First Quarter of Fiscal Year 2016 4Biosensors Reports Financial Results for the First Quarter of Fiscal Year 2016 5Biosensors Reports Financial Results for the First Quarter of Fiscal Year 2016 6/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 2/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 3/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 4/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 5/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 6Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 2Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 3Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 4Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 5Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 6Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 7Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 8Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 9Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 10Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 11Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 12
... , MOUNTAIN VIEW, Calif., ... ) a leading provider of medication system solutions to acute ... (CHS), the largest healthcare system in the Carolinas and third ... OmniRx® automated medication dispensing cabinets (ADCs) to streamline management of ...
... , PISCATAWAY, N.J., Dec. 3 ... recognized leader in advanced injection technologies, today announced that ... National Medicines Corporation Ltd. (d/b/a "Sinopharm") and Yichang Humanwell ... of China (the "PRC"), to develop orthopedic and epidural ...
Cached Medicine Technology:Omnicell Selected by Nation's Third Largest Public Healthcare System for Medication Management Systems 2Omnicell Selected by Nation's Third Largest Public Healthcare System for Medication Management Systems 3Omnicell Selected by Nation's Third Largest Public Healthcare System for Medication Management Systems 4Milestone Scientific to Establish Joint Venture to Develop Medical Drug Delivery Instruments 2Milestone Scientific to Establish Joint Venture to Develop Medical Drug Delivery Instruments 3
(Date:8/3/2015)... ... August 03, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce ... sweetFrog store operating in the Lone Star State. The premium frozen yogurt chain was ... , The store, located at 2916 US-75, Sherman, TX 38652, will have grand opening ...
(Date:8/3/2015)... ... August 03, 2015 , ... Since 1978, the number of black ... a new publication released today by the AAMC (Association of American Medical Colleges). ... the past three decades, the number of black male applicants to medical school dropped ...
(Date:8/3/2015)... ... August 03, 2015 , ... The Workgroup for Electronic Data Interchange ( ... create efficiencies in healthcare information exchange, announced the release of its findings from its ... Services (HHS) Secretary, WEDI shared survey results and recommendations , strongly ...
(Date:8/3/2015)... ... 2015 , ... According to an opinion piece published July 28 by the Washington ... pound of weight loss may not be accurate. While this system may work for some ... fat varies – based both on the individual and at what point that person is ...
(Date:8/3/2015)... ... August 03, 2015 , ... Bayer has agreed to pay $56.9 ... in which a claimant alleged to have suffered an arterial blood clot including stroke ... pills, Yaz, Yasmin and Ocella, has been ongoing for well-over five years. In 2009, ...
Breaking Medicine News(10 mins):Health News:sweetFrog Reopens Texas Store Today 2Health News:New Publication Focuses on the Decline of Black Males in Medicine 2Health News:New Publication Focuses on the Decline of Black Males in Medicine 3Health News:New Publication Focuses on the Decline of Black Males in Medicine 4Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 2Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 3Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 4Health News:Article Dispelling Weight Loss Myth Correctly Emphasizes the Complicated and Difficult Nature of Weight Loss, Says Dr. Michael Feiz 2Health News:Bayer Agrees To Settle Yaz Aterial Blood Clot Lawsuits 2
... Letter Carriers union President William H. Young told a House ... endangered by the greed and recklessness of financial firms and ... that would save the Postal Service billions of dollars in ... today to ask for a taxpayer bailout, but we are ...
... 25 In a medical world that tells parents ... child, a new study brings not only hope, but ... Daniel Rossignol, M.D., treats children with autism. Seeing his ... conduct the first large scale, double-blind, controlled study to ...
... at the National Institutes of Health have deciphered a ... that produce red and white blood cells remain anchored ... system. , An understanding of the factors that ... improved treatment of leukemia, a cancer that affects circulating ...
... MACON, Ga., March 25 Vickie Knight of Perry ... into the world in February 2008, but her joy turned ... was becoming increasingly flat on one side. Dawson developed plagiocephaly, ... one position in an infant carrier or crib. ...
... Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT ), ... commercialization of proprietary products that address important therapeutic needs ... of Joseph T. Kennedy to the position of Vice ... Mr. Kennedy will provide legal advice to the company ...
... ImQuest Life Sciences presented their latest biological results ... pyrimidinedione inhibitors of HIV-1 at the Prevention of ... highlighted new data supporting the selection of lead ... to the selection of drug resistant virus strains ...
Cached Medicine News:Health News:Young Tells Congress Survival of Postal Service Could Depend on Passage of Relief Legislation 2Health News:Autism Study Finds Significant Benefit with Hyperbaric Treatment 2Health News:Autism Study Finds Significant Benefit with Hyperbaric Treatment 3Health News:Researchers decipher blood stem cell attachment, communication 2Health News:Researchers decipher blood stem cell attachment, communication 3Health News:STARscanner, STARband Cranial Helmets Making a Difference in the Lives of Children 2Health News:STARscanner, STARband Cranial Helmets Making a Difference in the Lives of Children 3Health News:Transcept Pharmaceuticals Appoints Joseph T. Kennedy as General Counsel 2Health News:Transcept Pharmaceuticals Appoints Joseph T. Kennedy as General Counsel 3Health News:Transcept Pharmaceuticals Appoints Joseph T. Kennedy as General Counsel 4Health News:ImQuest Presentations at Keystone Symposium Focus on Advancements in Their Therapeutic and Microbicide Development Programs 2
... 6 pieces of 10 x 10 cm gel at ... cm for laboratories to dry several gels at once. ... Microprocessor controller controls temperature and timer. The gels are ... moisture from below to dry the gel homogeneously. When ...
... A compact air gel-drying system, Hoefers Easy Breeze can ... 20 cm) or 24 Mini-Gels (8 x 10 cm) ... need: an open air drying oven, a specially designed ... pump, no cold trap, no awkward connections., The Gel ...
... To dry gels rapidly, evenly and safely, ... method. Heat and vacuum are applied beneath the ... Dries acrylamide and agarose gels up to 33 ... minutes., The heavy aluminum platen provides even heat ...
... This HydroTech™ gel drying system, 100-120 V, ... and instructions. The Model 583 gel dryer is ... of 35 x 45 cm with variable temperature ... pump is a water-based pump used for pulling ...
Medicine Products: