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Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor,Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

Other Presentations at AACR Highlight Progress in SuperGen's Oncology-Focused Pre-Clinical Pipeline

LOS ANGELES, April 19, 2007 /PRNewswire-FirstCall/ -- SuperGen Inc. today announced that MP470, its multi-targeted tyrosine kinase inhibitor, suppresses the Rad51 protein, a critical component of double- stranded DNA repair in cancer cells as part of a series of presentations at the 2007 American Association for Cancer Research Annual Meeting (Abstract 4028).

Additional research findings presented by SuperGen scientists and their collaborators included data pertaining to the improved bioavailability and tolerability of the hydrochloride salt of MP470 as compared to the free base (Abstract 1540). Two posters also demonstrated the use of SuperGen's proprietary CLIMB technology and drug discovery process to facilitate lead development and the design of several novel small molecule inhibitors, including Axl kinase (Abstract 2380), as well as inhibitors of Jak2 (Abstract 2387).

The company also presented new animal model studies for small molecule inhibitors of DNMT1 in zebrafish (Abstract 2229), data from its preclinical compound MP529, a selective Aurora A kinase inhibitor (Abstract 3261) and new data exhibiting receptor tyrosine kinase inhibition in combination with an inhibitor of EGFR in mouse xenograft models (Abstract 5421). Finally, a mini- symposium was presented about work conducted at The Ohio State University on SuperGen's novel DNA hypomethylating agents that selectively induced degradation of DNMT1 in human cancer cells (Abstract 4142).

Copies of the poster presentations will be available in the pipeline section of SuperGen's Web site www.supergen.com.

"We are very encouraged by the strength of the preclinical data from our drug discovery and development programs and are awaiting the initiation of the Phase 1 clinical tri
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