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Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18

---------------------------------------------------------- Dose 3 ---------------------------------------------------------------------- Early** 2176.6 423.4 487 (1953.4, 2425.3) 521 (388.8, 461.2) ---------------------------------------------------------------------- On Time** 2415.0 486.0 2015 (2286.3, 2550.9) 2214 (464.7, 508.2) ---------------------------------------------------------------------- Late** 2765.9 498.5 326 (2408.7, 3176.2) 361 (446.2, 557.0) ---------------------------------------------------------------------- *Early = 36 to 50 days Postdose 1; On Time = 51 to 70 days Postdose 1; Late = 71 to 84 days Postdose 1. **Early = 80 to 105 days Postdose 2; On Time = 106 to 137 days Postdose 2; Late = 138 to 160 days Postdose 2. Note: GMT = Geometric mean titer in mMU/mL (mMU = milli-Merck units.) ---------------------------------------------------------------------- Bridging the Efficacy of GARDASIL from Young Adult Women to Adolescent Girls A clinical study compared anti-HPV 6, anti-HPV 11, anti-HPV 16, and anti-HPV 18 GMTs in 10- to 15-year-old girls with responses in 16- to 23-year-old adolescent and young adult women. Among subjects who received GARDASIL, 99.1 to 100% became anti-HPV 6, anti-HPV 11, anti-HPV 16, and anti-HPV 18 seropositive by 1 month Postdose 3. Table 5 compares the 1 month Postdose 3 anti-HPV 6, anti-HPV 11, anti-HPV 16, and anti-HPV 18 GMTs in 9- to 15-year-old girls with those in 16- to 26-year-old adolescent and young adult women. Table 5 Immunogenicity Bridging Between 9- to 15-year-old Female Adolescents and 16- to 26-year-old Adult Women ----------------------------------------------------------------------
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