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Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18

3.3, 51.7) ====================================================================== Prophylactic Efficacy* 8641 0 8667 24 100.0 (83.3, 100.0) ----------------------------------------------------- HPV 16- or 18- HPV 16 related VIN 2/3 and/or HPV and VaIN 2/3 18 Positive at Day 1 -- 8 -- 2 -- ----------------------------------------------------- General Population Impact** 8954 8 8962 26 69.1 (29.8, 87.9) ====================================================================== Prophylactic Efficacy* 8625 9 8673 143 93.7 (87.7, 97.2) ----------------------------------------------------- HPV 6-, 11-, HPV 6, HPV 16-, 18-related 11, HPV 16, CIN (CIN 1, CIN and/or HPV 2/3) or AIS 18 Positive at Day 1 -- 161*** -- 174*** -- ----------------------------------------------------- General Population Impact ** 8814 170 8846 317 46.4 (35.2, 55.7) ====================================================================== Prophylactic Efficacy* 8760 9 8786 136 93.4 (87.0, 97.0) ----------------------------------------------------- HPV 6-, 11-, HPV 6, HPV 16-, or 18- 11, HPV 16, related Genital and/or HPV Warts 18 Positive at Day 1 -- 49 -- 48+ -- ----------------------------------------------------- General Population Impact ** 8954 58 8962 184 68.5 (57.5, 77.0) ---------------------------------------------------------------------- *Includes all subjects who
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