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Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18

WHITEHOUSE STATION, N.J.--(BUSINESS WIRE)--May 17, 2007 - Results published this week in The Lancet show that Merck's cervical cancer vaccine, GARDASIL (Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine) was 100 percent effective in preventing high-grade vulvar and vaginal dysplasias caused by HPV types 16 and 18, two types strongly associated with these diseases. The 100 percent protection was observed in women who were not infected with HPV types targeted by the vaccine -- 6, 11, 16 and 18 -- at the start of the study and through one month after receiving the third dose. Data published in The Lancet represent an additional year of follow up since data were presented to the U.S. Food and Drug Administration (FDA) for approval of GARDASIL.

"This combined analysis provides additional data showing that GARDASIL protected against HPV-16 and 18 related high-grade vulvar and vaginal lesions in women ages 16-26," said Marc Steben, M.D., CCFP, family physician, HPV Scientific Group, Institut National de Sante Publique du Quebec, Canada. "Although HPV 16 and 18 do not cause all cases of vulvar and vaginal cancer, they account for a high proportion of cases in young women."

"We are pleased to report data that continue to show that GARDASIL helps to protect against the four HPV types known to cause genital warts and low grade lesions in addition to cervical cancer, and vulvar and vaginal pre-cancers," said Richard M. Haupt, M.D., MPH, executive director of Medical Affairs, Merck Vaccines.

GARDASIL was approved by the FDA on June 8, 2006, and is recommended for use by girls and women ages 11 to 26 by the U.S. Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices. GARDASIL is indicated for the prevention of HPV types 16- and 18- related cervical cancer, non-invasive cervical cancer (cervical intraepithelial neoplasia (CIN) grade 3 and adenocarcinom
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