Navigation Links
Data Presented at ASH Demonstrate Nebivolol Lowers Blood Pressure,as Long-Term Monotherapy and in Combination Therapy

Data Also Show Nebivolol Lowers Blood Pressure in Obese and Non-Obese Hypertensive Patients

CHICAGO, May 21, 2007 /PRNewswire-FirstCall/ -- Forest Laboratories, Inc. today presented positive data from two clinical studies and one pooled analysis of nebivolol, a selective beta 1-blocker with vasodilating properties currently under review by the U.S. Food and Drug Administration (FDA) for the treatment of hypertension. Data from the two clinical studies show that nebivolol demonstrates blood pressure lowering effects as long-term therapy either alone or in combination with other agents, and also as part of a combination treatment for hypertension. The pooled analysis of three registration monotherapy trials supports nebivolol's blood pressure lowering effects for the treatment of hypertension in obese individuals, a difficult- to-treat patient population. The data were presented at the American Society of Hypertension, Inc. (ASH) 22nd Annual Scientific Meeting and Exposition (ASH 2007) in Chicago.


    Data presented at ASH includes:

    -- "Long-Term Exposure to the Novel Beta-Blocker Nebivolol as Monotherapy

       or Combination Therapy: Antihypertensive Efficacy and Safety" by

       Vasilios Papademetriou, MD, Professor of Medicine, Georgetown

       University.  [Poster Presentation, P-419: Monday, May 21 from 12 pm to

       1 pm (Riverside Hall)]

       The long-term treatment effects of nebivolol were evaluated in a

       multicenter, 9-month extension study (n=845) of patients who

       successfully completed one of the three randomized, double-blind,

       placebo-controlled registration studies.  Patients received nebivolol

       monotherapy (5 mg, 10 mg, or 20 mg once daily) or nebivolol plus

       adjunct therapy (open-label diuretics or amlodipine).  Outcomes

       demonstrated that nebivolol treatment produced sustained blood pressure

       reductions for the duration of the study period and was well tolerated

       in all treatment groups.  No clinically significant changes in glucose

       or lipids were seen with nebivolol monotherapy during the study.

    -- "Addition of the Beta-Blocker Nebivolol to Ongoing Therapy in the

       Management of Mild-to-Moderate Hypertension" by Alan H. Gradman, MD,

       Chief, Division of Cardiovascular Diseases, The Western Pennsylvania

       Hospital.  [Poster Presentation, P-383: Monday, May 21 from 12 pm

       to 1 pm (Riverside Hall)]

       The blood pressure lowering effects and tolerability of nebivolol added

       to ongoing antihypertensive therapy in patients was evaluated in this

       12-week, randomized, double-blind, placebo-controlled study (n=669).

       Results indicate that, by comparison to placebo, nebivolol

       incrementally lowers blood pressure in mild to moderate hypertensive

       patients when added to ongoing antihypertensive therapy consisting of

       one or two medications from the following classes: ACE inhibitors,

       ARBs, or diuretics, with an incidence of reported adverse events

       similar to placebo.

    -- "Efficacy of the Novel Beta-blocker Nebivolol in Obese and Non-Obese

       Hypertensive Patients" by James R. Sowers, MD, Professor of Medicine

       and Physiology, Director Diabetes and Cardiovascular Center, University

       of Missouri. [Poster Presentation, P-442: Monday, May 21 from 12 pm to

       1 pm (Riverside Hall)]

       The blood pressure lowering effects of nebivolol was compared in non-

       obese and obese hypertensive patients, a population that typically has

       a poorer response to treatment and an increased need for multiple

       medications.   The pooled analysis of three randomized, double-blind,

       placebo-controlled trials of similar design was stratified by patient

       obesity status (BMI greater than or equal to 30 kg/m2) at baseline

       (obese, n=878; non-obese, n=1136).  Results suggest that once-

       nebivolol effectively lowers blood pressure to a similar extent in both

       obese and non-obese hypertensive patients.

"These study results are promising and add to the growing body of data that support nebivolol as a useful treatment for hypertension across a broad population of patients," says Neil Shusterman, MD, Senior Vice President, Clinical Development, Forest Research Institute. "We feel that nebivolol will offer patients and physicians a unique option for managing high blood pressure."

About Nebivolol

Nebivolol is a selective beta 1-adrenergic (cardioselective) receptor antagonist with vasodilating properties and is already approved and successfully marketed for the treatment of hypertension in more than 50 countries outside of North America.

About Forest Laboratories and Its Products

Forest Laboratories is a US-based pharmaceutical company dedicated to identifying, developing, and delivering products that make a positive difference in peoples' lives. Forest Laboratories' growing product line includes Lexapro(R) (escitalopram oxalate), an SSRI indicated for adults for the initial and maintenance treatment of major depressive disorder and generalized anxiety disorder; Namenda(R) (memantine HCl), an N-methyl D-aspartate (NMDA)-receptor antagonist indicated for the treatment of moderate to severe Alzheimer's disease; Benicar(R)* (olmesartan medoxomil), an angiotensin receptor blocker, and Benicar* HCT(R) (olmesartan medoxomil-hydrochlorothiazide), an angiotensin receptor blocker and diuretic combination product, each indicated for the treatment of hypertension; and Campral(R)* (acamprosate calcium), indicated in combination with psychosocial support for the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation.

    * Benicar is a registered trademark of Daiichi Sankyo, Inc., and C

      is a registered trademark of Merck Sante s.a.s., subsidiary of Merck

      KGaA, Darmstadt, Germany.

Except for the historical information contained herein, this release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These statements involve a number of risks and uncertainties, including the difficulty of predicting FDA approvals, the acceptance and demand for new pharmaceutical products, the impact of competitive products and pricing, the timely development and launch of new products, and the risk factors listed from time to time in the Forest Laboratories' SEC reports, including the Company's Annual Report on Form 10-K for the fiscal year ended March 31, 2006 and on Form 10-Q for the periods ended June 30, 2006, September 30, 2006 and December 31, 2006.

CONTACT: Charles E. Triano, Vice President, Investor Relations, of ForestLaboratories, Inc., +1-212-224-6714, ; or On-siteContact: Paddi Hurley of Fleishman-Hillard, +1-917-743-2290,, for Forest Laboratories, Inc.

Web site:

Ticker Symbol: (NYSE:FRX)

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


Related medicine technology :

1. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. Positive ZIO-201 Interim Phase II Sarcoma Data Presented at European Society for Medical Oncology
4. Clinical Data From Nymox BPH Drug To Be Presented at American Urological Association Meeting
5. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
6. ZIO-101 (Darinaparsin) Interim Phase II and Preclinical Data Presented at International Myeloma Workshop
7. Nymox Announces NX-1207 Data to Be Presented at Upcoming U.S. Urology Meetings
8. MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating MacroVascular Outcomes Presented at the American Diabetes Association 67th Scientific Sessions
9. Nymox Announces NX-1207 Data to Be Presented at Upcoming U.S. Urology Meetings
10. ConjuChem Biotechnologies Reports PC-DAC:Exendin-4 Albumin Conjugate Data Presented at American Diabetes Association Annual Meeting
11. New Data Presented on Micardis (Telmisartan) Tablets in Hypertensive Patients With Type 2 Diabetes
Post Your Comments:
(Date:11/25/2015)... , Nov. 25, 2015  Amgen (NASDAQ: ... License Application (BLA) with the United States ... ABP 501, a biosimilar candidate to Humira ® ... biosimilar application submitted to the FDA and represents Amgen,s ... Sean E. Harper , M.D., executive vice president ...
(Date:11/25/2015)... 25, 2015  The American Academy of Pediatrics ... and the March of Dimes cheered today,s signature ... Infants Act of 2015 (S.799), which takes ... born exposed to drugs, such as opioids, and ... all three organizations have worked together leading advocacy ...
(Date:11/25/2015)... 2015  Linden Care, LLC, a retail specialty pharmacy ... patients suffering from chronic pain, said today that it ... Order (TRO) enjoining Express Scripts from unilaterally terminating the ... --> --> The company said ... options. --> --> ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... November 25, 2015 , ... As ... Water For Empowerment ™ attracts volunteers together who want to combine talents and ... as key stakeholders in the process. The non-profit launched its first major fundraiser ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... the perfect dish and pleasing the palates of attendees is of the utmost ... dish to a seasonal get-together, give these recipes a try this holiday season. ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in the traditional and ... of traditional and far-infrared saunas. , For traditional saunas, Finnleo is offering ... Finnish sauna wood, and Finnleo uses only European Grade A Nordic White Spruce from ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... companies, has been recognized once again for its stellar workplace culture with the ... Work.” , Medical Solutions’ Cincinnati office was named a finalist in ...
(Date:11/25/2015)... MN (PRWEB) , ... November 25, 2015 , ... ... launched offering factory direct sauna parts and accessories. , Sauna accessories help ... of the bather’s style and personality. From basic styles for the purist looking ...
Breaking Medicine News(10 mins):