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Data Presented at AACR Meeting Shows Peregrine's Selective,Anti-VEGF Antibodies are as Effective as Avastin(R) in Preclinical,Cancer Models

s in mice. These positive results using a fully human antibody support Peregrine's intent to advance its anti-VEGF program towards clinical trials.

This research, which was conducted under the direction of Dr. Rolf Brekken, assistant professor of surgery at UT Southwestern Medical Center in Dallas, was supported in part by a sponsored research agreement with Peregrine Pharmaceuticals. The fully human antibody R3 used in these studies was developed in collaboration with Affitech AS of Norway. These studies were also supported in part by a postdoctoral fellowship from the Susan G. Komen for the Cure, the Effie Marie Cain Scholarship in Angiogenesis Research and the Department of Surgery at UT Southwestern.

Number 2128: Blockade of tumor-derived VEGF activation of VEGF receptor 2 reduces macrophage infiltration into tumors and decreases metastasis in a pre-clinical orthotopic model of pancreatic cancer, Juliet G. Carbon, Shane E. Holloway, Andrew F. Miller, Anita Kavlie, Kyle Schlunegger, Jason B. Fleming, Rolf A. Brekken. UT Southwestern Medical Ctr., Dallas, TX, Affitech AS, Oslo, Norway, Peregrine Pharmaceuticals Inc., Tustin, CA, UT-MD Anderson, Houston, TX, Apr 16, 2007, 8:00 AM -12:00 PM PDT

About Peregrine Pharmaceuticals

Peregrine Pharmaceuticals, Inc. is a biopharmaceutical company with a portfolio of innovative product candidates in clinical trials for the treatment of cancer and hepatitis C virus (HCV) infection. The company is pursuing three separate clinical programs for HCV infection and a range of solid cancers in the U.S. and India with its lead product candidates bavituximab and Cotara(R). Peregrine also has in-house manufacturing capabilities through its wholly owned subsidiary Avid Bioservices, Inc. (www.avidbio.com), which provides development and bio-manufacturing services for both Peregrine and outside customers. Additional information about Peregrine can be found at
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