Navigation Links
Data Presented at AACR Meeting Shows Peregrine's Immunocytokine,Fusion Proteins Reduce Growth of B-Cell Lymphoma Tumors by 85% in,Preclinical Studies

- New Studies Confirm That Fusion Proteins Made by Combining Cytokines With Peregrine's Anti-PS Antibodies Demonstrate Increased Anti-Tumor Activity With No Observable Toxicity -

LOS ANGELES and TUSTIN, Calif., April 18, 2007 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. , a clinical stage biopharmaceutical company developing targeted monoclonal antibodies for the treatment of cancer and hepatitis C virus infection, today reported that data presented at the Centennial Annual Meeting of the American Association for Cancer Research (AACR) showed that fusion proteins combining the anti-cancer cytokines alpha interferon and interleukin 2 (IL-2) with 2aG4, a bavituximab equivalent, demonstrated potent anti-cancer activity in preclinical models of B-cell lymphoma and melanoma. In these studies, the antibody-cytokine fusion proteins generated a robust anti-tumor response without any observable toxicity. These immunocytokine fusion proteins incorporating antibodies that target the blood vessels of tumors are new preclinical candidates under Peregrine's proprietary Vascular Targeting Agent (VTA) technology platform.

The use of VTAs to deliver cytokines specifically to tumor targets is an appealing approach since the anti-cancer utility of cytokines such as interferons and interleukin 2 has been limited by their short half-life and the systemic toxicity seen at high doses. VTA immunocytokines aim to overcome these problems by combining the immunomodulatory activity of the cytokine with the tumor specificity of a targeted antibody.

In these proof of principle studies, VTA immunocytokines were created by combining type I interferon and interleukin 2 with 2aG4, an anti-phospholipid antibody similar to Peregrine's bavituximab. The resulting immunocytokine fusion proteins were capable of selectively targeting tumor blood vessels and displayed potent anti-cancer effects in a number of tumor models wit
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. Positive ZIO-201 Interim Phase II Sarcoma Data Presented at European Society for Medical Oncology
4. Clinical Data From Nymox BPH Drug To Be Presented at American Urological Association Meeting
5. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
6. ZIO-101 (Darinaparsin) Interim Phase II and Preclinical Data Presented at International Myeloma Workshop
7. Nymox Announces NX-1207 Data to Be Presented at Upcoming U.S. Urology Meetings
8. MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating MacroVascular Outcomes Presented at the American Diabetes Association 67th Scientific Sessions
9. Nymox Announces NX-1207 Data to Be Presented at Upcoming U.S. Urology Meetings
10. ConjuChem Biotechnologies Reports PC-DAC:Exendin-4 Albumin Conjugate Data Presented at American Diabetes Association Annual Meeting
11. New Data Presented on Micardis (Telmisartan) Tablets in Hypertensive Patients With Type 2 Diabetes
Post Your Comments:
(Date:5/28/2015)... 28, 2015 Isis Pharmaceuticals, Inc. (NASDAQ: ... WebcastWhen: , Thursday, June 4 at 1:00 p.m. ET ... Live on the Internet.  Simply log onto our website ... the live event, a replay of the webcast will ... . ABOUT ISIS PHARMACEUTICALS, INC. Isis is ...
(Date:5/28/2015)... THE WOODLANDS, Texas , May 28, 2015 /PRNewswire/ ... announced today that Lexicon management will present at the ... at 8:00 a.m. Eastern Time in New ... of Lexicon,s clinical development programs and milestones. ... Lexicon,s website at www.lexpharma.com . An archived version ...
(Date:5/28/2015)... -- Compassion & Choices today is pleased to report that ... authorize the option of medical aid in dying for terminally ... The legislation, the End of ... adults with six months or less to live the option ... peacefully end an unbearable dying process. A vote on the ...
Breaking Medicine Technology:Webcast Alert: Akcea Therapeutics Conference Call 2Webcast Alert: Akcea Therapeutics Conference Call 3Lexicon To Present At The Jefferies 2015 Healthcare Conference 2California Committee Sends Medical Aid-in-Dying Bill to Senate Floor 2California Committee Sends Medical Aid-in-Dying Bill to Senate Floor 3
... Dec. 16, 2010 Neuro Kinetics, Inc. (NKI) ( ... worldwide to test for vestibular and neurological conditions, was ... Category)" by the Pittsburgh Business Times, the company said ... honor at a ceremony held in Pittsburgh earlier this ...
... ERT (Nasdaq: ERES ), a global provider ... medical device industries, today announced the launch of its ... the ePRO market continues to grow, ePRO tools have ... diverse needs of sponsors and facilitating compliance by the ...
Cached Medicine Technology:Neuro Kinetics Named 'Manufacturer of the Year' 2ERT Unveils Full Range of ePRO Solutions Providing the Power of Choice for Clinical Trial Sponsors 2ERT Unveils Full Range of ePRO Solutions Providing the Power of Choice for Clinical Trial Sponsors 3
(Date:5/28/2015)... Ross A. Clevens, MD, FACS, Brevard’s board ... as the new marketing director for Clevens Face and ... marketing and promotional events for the practice. Beard has ... compelling marketing strategies to achieve targeted results. Prior to ... guest communication manager at the Walt Disney World Resort ...
(Date:5/28/2015)... May 28, 2015 As the summer approaches, ... keep cool. It’s important to make safety a top priority, ... some swimming tips. , According to the Centers for Disease ... United States, not including boating incidents. Additionally, the National Safety ... children ages 1 to 4. , Amica is sharing ...
(Date:5/28/2015)... Pa (PRWEB) May 28, 2015 ISMETT ... in Palermo, Italy, boosted the Sicilian economy by €132.5 million ... a net benefit of more than €73 million by retaining ... care, according to a new study by the Battelle Memorial ... access to research, training and advanced health care management that ...
(Date:5/28/2015)... 28, 2015 Altima Technologies, Inc., ... Library for documenting and diagramming data center assets ... the following product lines: , Manufacturer / ... Chatsworth Products N-Series TeraFrame Cabinet, Middle Atlantic Products ... Fore Systems ForeRunner, Marantz America MM Series, Extron ...
(Date:5/28/2015)... May 28, 2015 The CEO and ... a just launched blog series which provides analysis on ... on the “R. Bruce Dalglish” profile on Blogger.com, this ... Bruce Dalglish’s corporate experience. , “Throughout my business ... cultures have upon the overall success of businesses,” stated ...
Breaking Medicine News(10 mins):Health News:Clevens Face and Body Specialists Welcomes Teresa Beard as Marketing Director 2Health News:Splash! Amica Shares 6 Swimming Safety Tips 2Health News:UPMC-Managed Transplant Hospital Drives Major Economic Benefits for Sicily, Study Finds 2Health News:UPMC-Managed Transplant Hospital Drives Major Economic Benefits for Sicily, Study Finds 3Health News:NetZoom™ Visio® Stencil Library Updates for EMC, Cisco, and Chatsworth Products 2Health News:R. Bruce Dalglish, CEO of Alliance Hospice, Introduces New Blog Series On Positive Corporate Culture 2
... are frequently used as a replacement for missing teeth ... appearance. Previous research demonstrates that the placement of a ... of the implant, so practitioners often focus their treatment ... tissue surrounding the implant. A recent study published in ...
... Kim Announces the Jobseekers Facelift Giveaway ContestSAN FRANCISCO, May ... David W. Kim has established a Jobseekers Facelift ... number of jobs, older applicants (those over 40) see ... stay competitive with younger applicants. "Of course, one,s accomplishments ...
... Women who take folic acid supplements for at least one ... having a premature baby by half, according to research published ... , The study links pre-conceptional folate supplementation of at least ... to 70 percent, regardless of age, race or other factors. ...
... not prevent spread of waterborne, disease-causing germs.COLORADO SPRINGS, ... ?subject=Swim%20Diaper%20Study" target="_new"> scientific study demonstrates that ... the most common cause of documented recreational water ... Scientists from the University of North Carolina-Charlotte ...
... New treatments are minimally invasive without the side ... video from the Society of Interventional Radiology at: ... CANCER A minimally invasive interventional radiology treatment -- ... as effective as surgery but without the side ...
... the MidwestO,FALLON, Ill. May 12 MEDS, a ... today that it has named G. Scott Dillon ... more than 25 years of experience in clinical ... as chief operating officer of NES Holding Inc. ...
Cached Medicine News:Health News:Placement of dental implants results in minimal bone loss 2Health News:Want to Help Your Job Hunt? Win a Facelift! 2Health News:Taking folic acid for a year before pregnancy may reduce risk of preterm birth 2Health News:New Study: Keep Kids With Diarrhea Out of Pool - Swim Diapers Not Best Solution 2Health News:New Study: Keep Kids With Diarrhea Out of Pool - Swim Diapers Not Best Solution 3Health News:VIDEO from Medialink and the Society of Interventional Radiology: Prostate and Kidney Cancer - New Life-Changing Developments 2Health News:G. Scott Dillon Named President and CEO of MEDS 2
... a finger into comfortable holder, measuring ... continuous measurement is performed., ,Large ... In darker surroundings, back light automatically ... ,Light weight, compact contour and design ...
... FingerPrint Sleep Hand-Held Pulse Oximeter with ... for sleep screening studies in the ... With its easy-to-use, 2-key operation, ... measurements of SpO 2 , pulse ...
... Program is a Windows based, easy-to-use software ... Pulse Oximeter. Using the Smiths Medical ... rapidly downloads information collected during sleep screening, ... assists in the Clinician's interpretation by analyzing ...
... want: ,Four probe choices, single degree control of ... in the industry, gives you the power and ... From full sulcus-to-sulcus measurements to detailed anatomy ... clarity of images and resolution you demand., ,A ...
Medicine Products: