( rine in conditions such as cancer sai...)Data Presented at AACR Meeting Show Peregrine's Bavituximab,Equivalent Can Generate Curative Immune Responses as Part of a,Vaccine-Like Regimen in Preclinical Models of Aggressive Brain,Cancer,Health

rine in conditions such as cancer," said Dr. Philip Thorpe, professor of pharmacology at the University of Texas Southwestern Medical Center and a member of the Peregrine Scientific Resource Board. "These new studies in animal models of aggressive brain cancer are the strongest evidence yet that this is the case. We are eager to explore further the promising immune-enhancing activity demonstrated by our anti-PS antibody against this lethal cancer."

Bavituximab is a targeted monoclonal antibody that binds to a phospholipid called phosphatidylserine (PS), which is normally located on the inside of cells, but which becomes exposed on the outside of the cells that line the blood vessels of tumors. Once bound to tumor blood vessels, bavituximab alerts the body's immune system to attack the tumor's blood supply, stopping the flow of oxygen and nutrients to the tumor cells and resulting in tumor cell death. PS is also thought to play a role in suppressing the body's immune response to cancer. PS blockers may have the potential to help reverse this suppression and enable the immune system to attack the cancer more effectively. As an anti-cancer immunotherapeutic, bavituximab may have broad potential in a wide variety of solid cancers. It is currently in Phase Ia cancer safety trials as a monotherapy and in a Phase Ib trial in combination with docetaxel and other chemotherapy agents in patients with advanced solid cancers, including prostate, breast and lung cancer. Based on interim data, more than half of the cancer patients in this study who have completed treatment to date were assessed as demonstrating stable disease or an objective response.

This research was conducted under the direction of Dr. Thorpe and postdoctoral researcher Dr. Jin He at UT Southwestern Medical Center in Dallas.

This work was supported in part by the Meredith C. Chestler Foundation, the Childhood Brain Cancer Foundation and the Gillson Longenbaugh Foundation and by a sponsored
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