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Data From Adherex's European Phase Ib/II Trial of ADH-1 to be,Presented at International Symposium on Targeted Anticancer,Therapies

RESEARCH TRIANGLE PARK, N.C., Mar 8, 2007 (CCNMatthews via COMTEX News Network) -- Adherex Technologies Inc. (TSX:AHX)(AMEX:ADH), a biopharmaceutical company with a broad portfolio of oncology products under development, today announced that Dr. Antonella Perotti, MD, Istituto Nazionale dei Tumori Milano, SENDO Foundation, an investigator in Adherex's European Phase Ib/II study of single-agent ADH-1, will present data today from that study at the 5th International Symposium on Targeted Anticancer Therapies in Amsterdam, The Netherlands.

The data includes 30 patients who received an aggregate of over 200 doses (68 cycles) of ADH-1 given on a weekly schedule with doses ranging from 150 to 2400 mg/m2. ADH-1 was well tolerated at all doses tested for periods of up to eight months, displayed predictable pharmacokinetics, and demonstrated hints of anti-tumor activity in five patients with advanced, chemotherapy-resistant cancer. A maximum tolerated dose was not defined.

"This European data is consistent with our prior clinical experience, showing ADH-1 to be well tolerated over a broad dosage range with hints of anti-tumor activity in a variety of tumor types," said William P. Peters, MD, PhD, Chairman and CEO of Adherex. "Given the unexpected level of synergy of ADH-1 in combination with chemotherapy that we have reported from our preclinical studies, the clinical development of this drug continues fully on track. We expect to have results from the North American Phase II trial with single-agent ADH-1 as well as initial results from our ongoing Phase I combination studies with ADH-1 and chemotherapy available later this year."

In the European Phase Ib/II study, three of 19 patients (16%) with ovarian/gynecological tumors experienced evidence of anti-tumor activity, one with an unconfirmed partial response (previously reported) and two with prolonged stabilization of their disease, which were previously
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