Navigation Links
Data Demonstrated Metastatic Melanoma Response to Investigational,Immunotherapy Ipilimumab

imumab. The primary endpoint of the study was to investigate the safety and clinical activity of various doses of ipilimumab. The study enrolled 88 patients with unresectable stage III or stage IV malignant melanoma in three cohorts receiving varying doses and regimens. Analysis of the data demonstrated:

    - Overall disease control - defined as objective responses (complete and

      partial) and stable disease - achieved in 19% (17/88) of patients.

      - In the cohort of 23 patients who were treated at 10 mg/kg, disease

        control was achieved in 39% (9/23), which lasted six months or longer

        in nearly all patients (8/9).

    - Duration of disease stabilization or response exceeded six months in 15%

      (13/88) of patients.  The longest effect observed (stable disease) is

      ongoing for more than a year.

Adverse events reported in this study were consistent with those immune- related adverse events (irAEs) results in other clinical trials of ipilimumab (diarrhea, rash, adrenal insufficiency, elevated liver enzymes). In this study, the overall incidence of irAEs was 72% (63/88). All patients who achieved a response (complete or partial responses) and most patients who achieved stable disease (12/13) also reported an irAE - primarily grade 1 or 2 with the exception of grade 3 diarrhea (1/88), adrenal insufficiency (1/88) and liver abnormalities (1/88) in three patients with stable disease. Twenty- eight percent (25/88) of patients reported serious adverse events (SAEs) regardless of causality, nine of which were ipilimumab-related, but not dose dependent. Most events were reversible without sequelae.

(Abstract #8525) Analysis of data aggregated from six Phase I and II trials, presented by Omid Hamid, MD, an investigator at The Angeles Clinic and Research Institute in Los Angeles, California, showed durable objective responses and stable disease in some patients who received varying doses of ipilimumab (0.1 up to
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine
2. Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic Control in Subjects with Type 2 Diabetes Compared to Metformin Alone
3. Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic Control in Subjects with Type 2 Diabetes Compared to Metformin Alone
4. Investigational Study Demonstrated a Re-Establishment of Clinical Improvement with Orencia (Abatacept) in Children with Juvenile Idiopathic Arthritis upon Re-Introduction of Therapy
5. Study Demonstrated Rozerem (ramelteon) Does Not Affect Middle-of-the-Night Balance in Older Adults with Insomnia
6. Repros Reports That Proellex Has Demonstrated Superior Efficacy and Safety in Endometriosis When Compared to Standard of Drug Care
7. Organons Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial as Compared to Neostigmine
8. Organons Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial Compared to Neostigmine
9. Trexima (Sumatriptan/Naproxen Sodium) Demonstrated Migraine-Free Response Across Multiple Attacks
10. Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
11. 12-Month Study Demonstrated Tolerability and Efficacy of DAYTRANA (methylphenidate transdermal system)
Post Your Comments:
(Date:8/4/2015)... 4, 2015 ANI Pharmaceuticals, Inc. ("ANI") (NASDAQ: ... three and six months ended June 30, 2015 and ... host its earnings conference call this morning, August 4, ... parties can join the call by dialing (855) 582-8078. ... Include: , Year-to-date net revenues of $38.3 million, an ...
(Date:8/4/2015)... Aug. 4, 2015  Ironshore Pharmaceuticals & Development, ... Health, a company specializing in personalized medicine, to ... trial, designed to evaluate the safety and efficacy ... treat Attention-deficit/hyperactivity disorder (ADHD). This is Restore,s second ... Health originally partnered with Ironshore in 2014 and ...
(Date:8/3/2015)... WEST JORDAN, Utah , Aug. 3, 2015  BC ... Solutions has acquired Ohio Valley Medical Systems, one of ... MRI systems.  The addition of Ohio Valley Medical Systems ... to now include Hitachi MRI.   "We ... Mark Alvarez , President and CEO of BC Technical. ...
Breaking Medicine Technology:ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 2ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 3ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 4ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 5ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 6ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 7ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 8ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 9ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 10ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 11ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 12ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 13ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 14ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 15ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 16Restore Health Secures Another Clinical Trial with Ironshore Pharmaceuticals & Development 2BC Technical Acquires Ohio Valley Medical Systems 2
(Date:8/4/2015)... ... August 04, 2015 , ... assistPoint Partners, ... innovation to consolidate oncology patient assistance programs. Through a secure web portal, assistPoint ... assistPoint is an enterprise level, cloud-based application and workflow solution. This provides cancer ...
(Date:8/4/2015)... ... August 04, 2015 , ... Rhode Island Medical Imaging (RIMI) is pleased ... Medical Building on Wake Robin Road in Lincoln, RI. This satellite office will ... the most extensive out-patient x-ray hours in the state, which includes evenings and weekends. ...
(Date:8/4/2015)... ... August 04, 2015 , ... An article published July ... be a viable method for encouraging people to lose weight. Specifically the study compared ... their weight loss success, adding a financial incentive to the overall incentive of increased ...
(Date:8/4/2015)... ... 04, 2015 , ... Angelina Jolie is in it at age 39. “It” ... Dr. Angela DeRosa, DO, MBA, CPE aka “Dr. Hot Flash,” arguably the ... out of menopause. , Myth #1: Menopause only affects old ladies. – Menopause ...
(Date:8/4/2015)... ... August 04, 2015 , ... Worldwide Power Products acquires ... expanding its reach in Texas. Effective July 1st of this year, Worldwide Power ... division. With the North Texas acquisition, Worldwide Power Products (“WPP”) now services ...
Breaking Medicine News(10 mins):Health News:assistPoint.com Web Site Launched 2Health News:Rhode Island Medical Imaging Opens Satellite Imaging Center on Wake Robin Road in Lincoln 2Health News:Article on Incentivizing Weight Loss Mirrors Similar Motivations Surrounding Weight Loss Surgery, Says Dr. Feiz & Associates 2Health News:"Dr. Hot Flash" Debunks the Top 5 Menopause Myths 2Health News:"Dr. Hot Flash" Debunks the Top 5 Menopause Myths 3Health News:North Texas Acquisition Press Release 2
... have identified a new gene family (UTX-JMJD3) essential for ... crucial for stem cell maintenance and differentiation, and the ... development of cancer. , The results are ... follows up on 2 other high-impact articles on related ...
... moments into the brain, study suggests , , WEDNESDAY, Aug. ... understand why frightening, traumatic memories go so deep and ... study in rats shows that a powerful neurochemical called ... trauma -- but it also "imprints" an emotional fear ...
... of secondary procedures , , TUESDAY, Aug. 21 (HealthDay News) ... peritonitis may not automatically need to undergo more operations ... In the United States, most surgeons choose to wait ... surgery, said Dr. David Flum, a gastrointestinal surgeon at ...
... highly effective in preventing the behavioral and academic problems ... a five-year study led by researchers at Lehigh Universitys ... and funded by the National Institute of Mental Health ... children aged 3 to 5 who have shown significant ...
... at the University of Liverpool that has identified a ... content of the diet. , Researchers found that the ... is not only present in the tongue, but also ... for the treatment of diabetes and obesity, as well ...
... be deadly , The Internet is serving as ... ideas about HIV/AIDS, which could have terrible public health ... Medicine. , "It may seem remarkable that, 23 years ... that the virus is the cause of AIDS," say ...
Cached Medicine News:Health News:Study Probes Roots of Fearful Memories 2Health News:One Surgery Often Enough for Peritonitis 2Health News:Non-medicinal treatment touted for pre-schoolers with ADHD 2Health News:Non-medicinal treatment touted for pre-schoolers with ADHD 3Health News:Discovery of 'sugar sensor' in intestine could benefit diabetes 2Health News:HIV denialists spread misinformation online -- consequences could be deadly; and more 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: