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DOR BioPharma Announces Publication Describing Results of Its,Multivalent Botulinum Toxin Vaccine BT-VACC

l block the uptake of the toxin before entering the bloodstream and reaching peripheral nerves. BT-VACC™ originated from the work of Lance Simpson, PhD, and has been exclusively licensed from Jefferson Medical College.

"These results are a major step forward and represent the first demonstration of a multivalent vaccine that is active by the mucosal route," said Christopher J. Schaber, PhD, President and CEO of DOR. "We think that these results in animals demonstrate the potential of developing subunit vaccines that can be given by a mucosal route, avoiding the use of needles and injections, with greater ease of administration and convenience for the provider and the patient. Such vaccines would further have the advantage to stimulate antibodies that block absorption of toxin into the body. We expect that the successful development of a multivalent oral botulinum toxin vaccine that can be applied to rapidly deployable mass immunization programs will be a major step forward in Biodefense countermeasures."

"These results are valuable for two reasons," added Lance L. Simpson, PhD, Professor of Medicine and Director of the Center for Research on Bioterrorism and Biodefense at Jefferson Medical College. "First, they are a clear demonstration that it is feasible to create an inhalation or intranasal vaccine against the three botulinum serotypes that are of greatest concern to human health. Second, and looking toward the future, the results are a promising indicator that it should be possible to create an oral vaccine. There is a consensus among immunologists and public health officials that oral vaccination is one of the most desirable ways to protect vulnerable populations against toxic substances."

Because the toxin naturally enters lung and intestinal tissues very efficiently, it is specifically possible to engineer a botulinum vaccine that can be administered orally or via nasal administration. Unpublished results have also shown that oral a
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