Navigation Links
DNA Therapeutics Reports a Novel Mechanism of Action and a,Biomarker of its Lead Molecule Dbait That Open an Innovative,Pathway-Targeting in Molecular Cancer Therapy

zation at chromatin level.

It is known that the kinases ATM/ATR and DNA-PK are involved in the general cellular response to DNA damage by signaling proteins that control cell cycle, apoptosis and DNA repair. In particular, ATM and DNA-PK both phosphorylate the H2AX, an isoform of the histone H2A, after exposure to ionizing radiation. The appearance of the phosphorylated H2AX, called gamma-H2AX, in cell nuclei is an indicator of DSB repair foci.

Our data provides evidence that Dbait specifically activates DNA-PK but not ATM kinase activity, as the phosphorylation of H2AX is in a DNA-PK dependent manner. Dbait-induced H2AX phosphorylation persists more than 6 days as compared to 1 day for irradiation. Cell imaging shows that the global distribution of gamma-H2AX in the nucleus of the cells transfected by Dbait was radically different of the gamma-H2AX foci organization observed when H2AX phosphorylation was triggered by irradiation alone. This indicates that DSB repair system is dramatically disorganized in Dbait transfected cells, and points out a new mechanism of action.

In addition, the amount of gamma-H2AX is proportional to that of Dbait in cultured cells and in the cells from tumor samples. gamma-H2AX appears to be a specific biomarker of Dbait in cells. It can be easily used to monitor the bioactivity of Dbait molecules in further preclinical and clinical development.

M. Dutreix who conducted this study said "this additional mechanism of antitumoral action of Dbait molecules confirms that the use of Dbait which baits, hijacks the enzyme complexes that repair DSBs and disorganizes DSB repair system, is a novel and attractive pathway-targeting approach in molecular cancer therapy".

J.S. Sun, CEO of DNA Therapeutics comments "The elucidation of Dbait's mechanisms of action and the identification of gamma-H2AX as a specific biomarker of Dbait activity are important milestones of DNA Therapeutics' development". He adds "DNA Therape
'"/>




Page: 1 2 3

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
5. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
6. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
7. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
8. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
9. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
10. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
11. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
Post Your Comments:
(Date:6/2/2015)... 2, 2015 The Canadian Society for Vascular Surgery ... treatments or procedures that are commonly ordered but ... of Choosing Wisely Canada.  The list identifies five ... between patients and physicians about what care is ... Vascular Surgery,s list identified the following five (5) ...
(Date:6/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/sn8mlw/picture_archiving ) has announced the ... - Global Strategic Business Report" report to their offering. ... US, Canada , Japan ... , Latin America , and Rest of ... the period 2014 through 2020. Also, a seven-year historic analysis ...
(Date:6/2/2015)... 2015 Intarcia Therapeutics, Inc. today ... its recently announced synthetic royalty / equity convert financing, ... have purchased Convertible Limited Recourse Notes from Intarcia and ... of any future global net sales of ITCA 650 ... also have the option, commencing upon U.S. regulatory approval ...
Breaking Medicine Technology:As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 2As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 3As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 4Picture Archiving and Communication Systems (PACS) - Global Strategic Business Report 2015: User Demand Favors Integrated RIS/PACS Solutions 2Intarcia Exercises Re-Opener For Its Recently Closed Royalty / Equity Convert Financing - Raising Total To $300 Million 2Intarcia Exercises Re-Opener For Its Recently Closed Royalty / Equity Convert Financing - Raising Total To $300 Million 3
... Dec. 17 A leading cancer physician and,researcher ... network specializing in Phase I - Phase IV ... trial conducted to,increase pathologic complete response (pCR) and ... subsequent pCR for patients with,stage 2 and 3 ...
... SuperGen, Inc.,(Nasdaq: SUPG ) today ... in a multi-arm Phase 1b clinical trial ... inhibitor (TKI). The trial will evaluate,MP470 in ... regimens,including carboplatin/paclitaxel, carboplatin/etoposide, docetaxel,topotecan, and erlotinib. The ...
Cached Medicine Technology:US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium 2US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium 3US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium 4SuperGen Reports Initiation of Multi-arm Phase 1b Trial of Novel Tyrosine Kinase Inhibitor 2SuperGen Reports Initiation of Multi-arm Phase 1b Trial of Novel Tyrosine Kinase Inhibitor 3
(Date:6/2/2015)... 02, 2015 TU-Automotive Detroit is the ... The 150+ speakers include senior execs from GM, Chrysler, ... will provide a crucial status update on the automotive ... is just 24 hours to secure one of the ... can’t wait for tomorrow. There are 70 sessions looking ...
(Date:6/2/2015)... Relias Learning , the ... the healthcare market, is partnering with the National ... complimentary courses relating to mental health and wellness. ... additional resources to better understand and handle difficult ... first responders to situations involving people with mental ...
(Date:6/2/2015)... DuPont Pioneer , one of the ... warehouse and office facility in Zambia that will increase ... local and export markets to Kenya, Tanzania and other ... the breadbasket for southern Africa provided an enabling agricultural ... Central Africa senior business manager of DuPont Pioneer “Our ...
(Date:6/2/2015)... 02, 2015 Visiting Nurse Association ... of home health care, hospice and community services, ... CEO, Steve Landers, MD, MPH, to the Visiting ... , VNAA is a national association based ... mission driven, nonprofit providers of home and community-based ...
(Date:6/2/2015)... TranSlice: Reveal from Pixel Film Studios brings ... allows Final Cut Pro X users to transition from clip ... next screen. , TranSlice Reveal brings back the split screen ... X users can now transition from one screen to ... panel orientation and direction covered, no transition will look like ...
Breaking Medicine News(10 mins):Health News:The Connected Car’s Biggest Event is Here – TU-Automotive Detroit 2015 2Health News:Relias Learning Partners with Behavioral Health and Developmental Disabilities Leaders to Offer Complimentary Resources to Public Safety Professionals 2Health News:Relias Learning Partners with Behavioral Health and Developmental Disabilities Leaders to Offer Complimentary Resources to Public Safety Professionals 3Health News:Investing in Infrastructure Critical to Advancing Food Security in Zambia 2Health News:Investing in Infrastructure Critical to Advancing Food Security in Zambia 3Health News:Steve Landers, MD, MPH, President and CEO of VNA Health Group Appointed to VNAA Board of Directors 2Health News:Steve Landers, MD, MPH, President and CEO of VNA Health Group Appointed to VNAA Board of Directors 3Health News:Announcing the release of TranSlice Reveal from Pixel Film Studios - Professional Split Screen Transitions for FCPX. 2
... the Ramazzini Institute for cancer research in Italy say their ... laboratory animals "at doses very close to the acceptable daily ... that while rats fed aspartame ate less food, there was ... The study was performed in 1,800 rats during their full ...
... hay fever or any of the allergic conditions can reduce ... be fatal. ,Variations in certain genes in adults can ... asthma and other allergic reactions. And these gene variations also ... cancer in the same adults. The researchers of Ohio State ...
... has recently approved human volunteer trials for the country's second ... A vaccine for the developing world, where anti-retroviral drugs are ... the ultimate prize in the fight against AIDS. But efforts ... to mutate. ,After South Africa , India has ...
... Ongole town in Andhra Pradesh has started using its public ... departures of trains but also messages about how to prevent ... India has high incidence of prostitution and AIDS. ,Says ... HIV/AIDS like mad. I witness a lot of homosexual activity ...
... lived longer than patients// given a placebo. ,Lung cancer ... women. Two studies were conducted by Canadian –led international research ... first study was conducted by Dr. Timothy Winton of the ... study was done to prove that if chemotherapy is given ...
... or panoramic radiographs can be effective in detecting blocked// ... a stroke. ,Researchers from Virginia Commonwealth University School ... find out about the oral health of the patient ... blocked carotid artery in the patient. ,The ...
Cached Medicine News:Health News:Can Ajinomoto cause cancer? 2Health News:The Indian Government has given the nod to conduct Human volunteer trials inorder to develop preventive AIDS vaccines 2Health News:Drug Tarceva for End-stage Lung cancer 2
Round handle dull finish. For right handed surgeon....
Specially designed wider jaws to help split soft nucleus, cross action, round handle, maximum opening 2.8 mm....
Irrigating nucleus chopper, tip angled 30 to side wedge shaped inferior edge with blunt tip and front notch for engaging iris end opening, 19 gauge. For use in the right hand....
Irrigating nucleus chopper, 0.6 mm dual sideports, 20 gauge. For the right handed surgeon....
Medicine Products: