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DNA Therapeutics Reports a Novel Mechanism of Action and a,Biomarker of its Lead Molecule Dbait That Open an Innovative,Pathway-Targeting in Molecular Cancer Therapy

EVRY, France, April 12, 2007 /PRNewswire/ -- DNA Therapeutics S.A. an emerging pharmaceutical company specialized in innovative cancer therapy announces today the elucidation of a new mechanism of action and the identification of a biomarker of its first-in-class antitumoral lead molecule Dbait. It will be presented at the forecoming American Association for Cancer Research annual meeting 2007. Its abstract is now available online. The presentation itself will be available from April 16th onwards at http://www.dna-therapeutics.com/doc/File/pdf/AACR2K7.pdf

Background: Most of the cancer therapies induce directly or indirectly DNA double strand breaks (DSBs), but unfortunately cells possess DNA repair complexes specialized in repairing these lethal lesions, which are responsible of lessened efficacy, or refractoriness of classical therapies.

A new family of anticancer drugs, named short inhibiting DNA (siDNA), has been designed by DNA Therapeutics' scientific founder team to inhibit these repair activities. The first lead, named Dbait, mimics DSBs, diverts DSB repair system from their primary objective, and facilitates cancer cells killing by traditional therapies.

The proof of concept work was presented last November at the 18th EORTC-NCI-AACR Symposium "Molecular Targets and Cancer Therapeutics" (Prague): the median survival of nude mice grafted with human tumor cell lines treated by intra-tumoral injection of Dbait, in association with radiotherapy, is significantly increased in a dose-dependent manner. MRI and cytology analysis of tumors shows that Dbait strongly enhances irradiation-induced necrosis and apoptosis.

New finding: The present study aims at deciphering the underlying mechanism of action of Dbait at molecular and cellular levels, and in particular its impact on DSB repair foci organi
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