Navigation Links
DNA Therapeutics Reports a Novel Mechanism of Action and a,Biomarker of its Lead Molecule Dbait That Open an Innovative,Pathway-Targeting in Molecular Cancer Therapy

EVRY, France, April 12, 2007 /PRNewswire/ -- DNA Therapeutics S.A. an emerging pharmaceutical company specialized in innovative cancer therapy announces today the elucidation of a new mechanism of action and the identification of a biomarker of its first-in-class antitumoral lead molecule Dbait. It will be presented at the forecoming American Association for Cancer Research annual meeting 2007. Its abstract is now available online. The presentation itself will be available from April 16th onwards at http://www.dna-therapeutics.com/doc/File/pdf/AACR2K7.pdf

Background: Most of the cancer therapies induce directly or indirectly DNA double strand breaks (DSBs), but unfortunately cells possess DNA repair complexes specialized in repairing these lethal lesions, which are responsible of lessened efficacy, or refractoriness of classical therapies.

A new family of anticancer drugs, named short inhibiting DNA (siDNA), has been designed by DNA Therapeutics' scientific founder team to inhibit these repair activities. The first lead, named Dbait, mimics DSBs, diverts DSB repair system from their primary objective, and facilitates cancer cells killing by traditional therapies.

The proof of concept work was presented last November at the 18th EORTC-NCI-AACR Symposium "Molecular Targets and Cancer Therapeutics" (Prague): the median survival of nude mice grafted with human tumor cell lines treated by intra-tumoral injection of Dbait, in association with radiotherapy, is significantly increased in a dose-dependent manner. MRI and cytology analysis of tumors shows that Dbait strongly enhances irradiation-induced necrosis and apoptosis.

New finding: The present study aims at deciphering the underlying mechanism of action of Dbait at molecular and cellular levels, and in particular its impact on DSB repair foci organi
'"/>




Page: 1 2 3

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
5. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
6. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
7. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
8. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
9. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
10. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
11. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
Post Your Comments:
(Date:1/23/2015)... Jan. 23, 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... in the development and sale of patented biopharmaceutical medicine, ... pharmaceutical ingredients (API) today announced the business and development ... 1. Following the September 2014 JCM application ...
(Date:1/22/2015)... BOULDER, Colo. , Jan. 22, 2015  BiOptix is ... Klakamp as Vice President of Chemistry and Biochemistry. Scott ... Takeda Pharmaceuticals, AstraZeneca Pharmaceuticals, and Amgen throughout the course ... and development. "Scott is a nationally recognized ...
(Date:1/22/2015)... RMD ) today announced results for its quarter ... million, a 10 percent increase compared to the quarter ended ... currency basis). Net income was $91.2 million, an increase of ... Diluted earnings per share for the quarter were $0.64, an ...
Breaking Medicine Technology:TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11
... NEW YORK, Nov. 18, 2010 Reportlinker.com announces ... in its catalogue: TOP 10 ... FORECASTS http://www.reportlinker.com/p0330501/TOP-10-DRUG-DISCOVERY-TECHNOLOGIES-–-STRATEGIC-ANALYSIS-AND-GLOBAL-FORECASTS.html ... analysis and global forecasts (2010 to 2015) ...
... Reportlinker.com announces that a new market research ... Global HPLC Systems & Accessories Industry ... report analyzes the worldwide markets for HPLC Systems ... Product Segments: HPLC Pumps, HPLC Sample Injectors, HPLC ...
Cached Medicine Technology:Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 2Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 3Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 4Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 5Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 6Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 7Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 8Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 9Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 10Reportlinker Adds TOP 10 DRUG DISCOVERY TECHNOLOGIES - STRATEGIC ANALYSIS AND GLOBAL FORECASTS 11Reportlinker Adds Global HPLC Systems & Accessories Industry 2Reportlinker Adds Global HPLC Systems & Accessories Industry 3Reportlinker Adds Global HPLC Systems & Accessories Industry 4Reportlinker Adds Global HPLC Systems & Accessories Industry 5Reportlinker Adds Global HPLC Systems & Accessories Industry 6Reportlinker Adds Global HPLC Systems & Accessories Industry 7Reportlinker Adds Global HPLC Systems & Accessories Industry 8Reportlinker Adds Global HPLC Systems & Accessories Industry 9Reportlinker Adds Global HPLC Systems & Accessories Industry 10Reportlinker Adds Global HPLC Systems & Accessories Industry 11Reportlinker Adds Global HPLC Systems & Accessories Industry 12Reportlinker Adds Global HPLC Systems & Accessories Industry 13Reportlinker Adds Global HPLC Systems & Accessories Industry 14Reportlinker Adds Global HPLC Systems & Accessories Industry 15Reportlinker Adds Global HPLC Systems & Accessories Industry 16Reportlinker Adds Global HPLC Systems & Accessories Industry 17Reportlinker Adds Global HPLC Systems & Accessories Industry 18Reportlinker Adds Global HPLC Systems & Accessories Industry 19
(Date:1/22/2015)... LunaDress, with its top dressmaking technologies, has been a ... is showing its latest designs of wedding dresses and launching ... company’s CEO, all the fresh new products are designed for ... to 80% off. All the clothes from LunaDress follow up ...
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ ... Alliance (PPHA). The PPHA's passion for others' well-being and ... greats, treated for obstructive sleep apnea (OSA) has propelled them ... in the valley. The most recent plans for an event ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue ... means to “Live Fearless.” , The “Faces of ... stories about how they or someone they know has faced ... in the moment. By telling these types of stories through ...
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting the ... , Purchasing an accidental death and dismemberment rider for ... of rider provides benefits if the insured dies in an ... form of life insurance. , AD&D is not expensive ...
Breaking Medicine News(10 mins):Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... that nearly 55 percent of Americans, mostly women, are ... and brittle bones// that causes higher susceptibility to bone ... found to contribute to lower bone mineral density in ... PhD, director of the Epidemiology and Dietary Assessment Program ...
... ENBRELR (etanercept) safe to be used to treat psoriasis up ... result of the current studies were presented at the 15th ... a 'Biologic Medicine which means it is synthesized using recombinant ... of biotechnology. , , ,This biologic medicine acts ...
... for their future good health, says a new study//.John Reilly ... nurseries in Glasgow. ,The researchers monitored the children ... minutes, three times a week, reported the online edition of ... to affect the children's body mass index (BMI), the researchers ...
... The mosquito-borne dengue disease continued to take its toll across ... 3,000 suffering// from it even as the government maintained the ... Anbumani Ramadoss said: "The situation is not that of an ... will see a decreasing trend in the next two-three days. ...
... their cholesterol levels down for decades, ever since studies showed ... in recent years, experts have suggested that some people should ... type of cholesterol called low-density lipoprotein for some high-risk people ... medications to get there. ,Not so fast, says a ...
... stumbled upon some very interesting results following her study ... genetic characteristics of alcoholics, which ultimately determine which drugs ... drink. ,The urge to consume alcoholic drinks can ... investigations done by the researcher highlights which characteristics of ...
Cached Medicine News:Health News:Consumption of Colas Increase Risk of Osteoporosis in Older Women 2Health News:Consumption of Colas Increase Risk of Osteoporosis in Older Women 3Health News:Enbrelr Enters Safer Zone After Recent Research 2Health News:India registers 3,000 dengue patients, toll crosses 40 2Health News:India registers 3,000 dengue patients, toll crosses 40 3Health News:India registers 3,000 dengue patients, toll crosses 40 4Health News:No Clear Evidence for Ultra-Low Cholesterol Targets? 2Health News:No Clear Evidence for Ultra-Low Cholesterol Targets? 3Health News:No Clear Evidence for Ultra-Low Cholesterol Targets? 4
Prolactin EIA Reproductive Markers 025-BC-1037...
FSH EIA Reproductive Markers 025-BC-1029 Follicle Stimulating Hormone...
... is a C21 steroid hormone containing a ... C-4 and C-5 (?4).,This steroid hormone is ... with estrogens, regulates,the accessory organs during the ... in preparing the,endometrium for the implantation of ...
... Converting Enzyme (ACE), also known as Kininase ... with a molecular weight of at least ... a single polypeptide chain, a polysaccharide residue ... in many different cell types such as ...
Medicine Products: