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Cytos Biotechnology Reports Results from Phase IIa Study with,CYT003-QbG10 in Patients Suffering from Atopic Dermatitis

ent. The Immunodrug™ candidates are developed both in-house and together with Novartis and Pfizer Animal Health. Founded in 1995 as a spin-off from the Swiss Federal Institute of Technology (ETH) in Zurich, the company is located in Schlieren (Zurich). Currently, the company has 129 employees. Cytos Biotechnology AG has been listed on the SWX Swiss Exchange (SWX:CYTN) since October 2002.

References
1 Prevention of Allergy and Allergic Asthma (2003), World Health Organization (WHO).
2 Atopic Dermatitis (2003), National Institutes of Health, Publication No. 03-4272.

Glossary
Atopic dermatitis: a chronic skin disease; a certain type of eczema. Is accompanied by an inherited tendency to develop allergic diseases.
Disease-modifying: in contrast to symptomatic treatment, a disease-modifying treatment aims at addressing the cause of disease and to modify disease progression.
DNA: deoxyribonucleic acid; genetic information of an organism.
Double-blind: a set-up often applied in clinical trials where neither the doctor nor the patient knows if placebo or the active drug substance is applied.
EASI: Eczema Area and Severity Index (EASI), a commonly applied test to assess the extent and severity of AD.
Hypersensitivity: an excessive immune reaction. Immunotherapeutic: a product aimed at activation of the immune system to modify and interfere with a certain disease process.
Monotherapy: treatment with one drug as opposed to combination therapy. Here the term refers to treatment with CYT003-QbG10 alone in contrast to a regimen where CYT003-QbG10 is combined to an allergen extract (i.e. CYT005-AllQbG10).
Phase IIa: a clinical trial that examines a new drug candidate’s safety and exploratory efficacy and may include
between 10 and 100 patients.
Placebo: dummy medical treatment.
QbG10: Cytos Biotechnology’s Immunodrug™ Qb filled with the immunostimulatory D
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