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Cytokinetics Announces Non-clinical Data to be Presented at the,2007 AACR Annual Meeting

Four Posters Relating to Company Oncology Programs to be Presented

SOUTH SAN FRANCISCO, Calif., April 09, 2007 /PRNewswire-FirstCall/ -- Cytokinetics, Incorporated announced today that four posters containing non-clinical data will be presented at the 2007 Annual Meeting of the American Association for Cancer Research (AACR) to be held from April 14- 18, 2007 in Los Angeles, CA. These posters are related to multiple oncology programs at Cytokinetics and will present data evaluating ispinesib, a novel inhibitor of Kinesin Spindle Protein (KSP), in models of multiple myeloma, data evaluating GSK-923295, a novel inhibitor of centrosome associated protein E (CENP-E) in both biochemical assays and in xenograft models and data from a separate, novel Cytokinetics' cell-based drug discovery program.

    Poster Presentations at 2007 AACR Annual Meeting


    Ispinesib:


     Abstract #1435:  Kinesin Spindle Protein Inhibition for the Treatment of

     Multiple Myeloma. (Poster displayed on Sunday, April 15, 2007, 1:00 PM -

     5:00 PM, PT, Poster Section 27, Poster Board 16.)


    GSK-923295:


     Abstract #1522:  GSK-923295, a Potent and Selective CENP-E Inhibitor, Has

     Broad Spectrum Activity Against Human Tumor Xenografts in Nude Mice.

    (Poster displayed on Sunday, April 15, 2007, 1:00 PM - 5:00 PM, PT, Poster

     Section 31, Poster Board 8.)


     Abstract #3179:  Detailed Biochemical Analysis of the CENP-E Inhibitor

     GSK-923295. (Poster displayed on Monday, April 16, 2007, 1:00 PM - 5:00

     PM, PT, Poster Section 26, Poster Board 18.)


    Cell-based Drug Discovery Program:


     Abstract #5576:  Cell-based Discovery and Anti-tumor Activity of a Novel

     Mitotic Inhibitor. (Poster displayed on Wednesday, April 18, 2007, 8:00

     AM -12:00 PM, PT, Poster Section 27, Poster Board 14.)

Ispinesib has been the subject of a broad Phase II clinical trials program unde
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