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Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity,and Safety Profile of Quadramet at International Myeloma Workshop

PRINCETON, N.J.--(BUSINESS WIRE)--Jun 28, 2007 - Cytogen Corporation (NASDAQ: CYTO) reported updated data from a Phase 1 dose escalation study evaluating QUADRAMET(R) (samarium Sm-153 lexidronam injection) in combination with bortezomib (Velcade(R), Millennium Pharmaceuticals, Inc.) in patients with relapsed multiple myeloma. Data from 33 patients were presented today in a poster titled, "Phase 1 Trial of Bortezomib (Vel) and Samarium (Sam) in Multiple Myeloma," by James Berenson, M.D., Medical & Scientific Director of the Institute for Myeloma & Bone Cancer Research in West Hollywood, California, at the XIth International Myeloma Workshop taking place in Greece.

Results from this study demonstrated that the combination was tolerable and of 32 evaluable patients, 15 participants, or more than 46% achieved a response or stabilization of their disease. Of these, six patients responded to the combination regimen, with three achieving a complete response (CR) and three achieving a minor response (MR). Of the 15 patients who achieved either a response to treatment or stabilization of their disease, nine had previously failed treatment with bortezomib.

"For years we have known that radiopharmaceuticals, such as QUADRAMET, are an effective palliative treatment for patients with metastatic bone disease," said Michael D. Becker, president and chief executive officer of Cytogen. "The data from this Phase 1 study suggest that administration of QUADRAMET is safe and may also have anticancer activity when used in combination with bortezomib and should be studied further in this setting. Cytogen is committed to developing and commercializing innovative products, like QUADRAMET, for cancer patients, and these results support our ongoing development plan investigating additional synergistic combinations and patient populations that may benefit from this important therapy."

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