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Cytochroma Reports Positive Phase I Clinical Data for CTA018,Injection

designed to be both a strong activator of the Vitamin D signaling pathway and a potent inhibitor of CYP24, the intracellular enzyme responsible for normal catabolism of Vitamin D hormones. Based on its mechanism of action, CTA018 is expected to be effective in treating secondary hyperparathyroidism but safer than currently available therapies. This compound was specifically designed by Professor Gary H. Posner, Ph.D. and is protected under patents and patent applications exclusively licensed to Cytochroma Inc. from the Johns Hopkins University.

About Chronic Kidney Disease and Secondary Hyperparathyroidism

Vitamin D hormones and their analogues are currently used to treat secondary hyperparathyroidism in CKD and end-stage renal disease. According to the National Kidney Foundation, more than nine million North American patients suffer from moderate to severe CKD. Many develop Vitamin D insufficiency and secondary hyperparathyroidism which, if untreated, can cause debilitating bone diseases and increased patient morbidity and mortality. North American sales of Vitamin D therapies for the treatment of secondary hyperparathyroidism currently exceed $500 million per year and are expected to grow rapidly with the increasing incidence of CKD. CKD is most frequently caused by diabetes or hypertension, both of which are consequences of the widening North American epidemic of obesity.

About Cytochroma Inc.

Cytochroma (www.cytochroma.com) is a specialty pharmaceutical company engaged in the development and commercialization of proprietary products to treat and prevent the clinical consequences of Vitamin D insufficiency. The Company has an advanced portfolio of new therapies for Vitamin D insufficiency and secondary hyperparathyroidism associated with CKD. In addition, the Company is developing novel therapies to treat hyperproliferative disorders, such as cancer and psoriasis, and hyperphosp
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