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CytRx Announces Positive Results of Arimoclomol in Preclinical,Stroke Recovery Studies

advantages, the relatively large therapeutic window could dramatically simplify patient enrollment compared with other stroke studies, which will allow us to conduct relatively cost-effective clinical trials in relatively short timeframes. We have begun developing a potential Phase II clinical plan for arimoclomol in stroke recovery."

About Stroke

According to the American Heart Association, every 45 seconds on average someone in the United States has a stroke, and every three minutes someone dies of stroke. Stroke is the third leading cause of death in the U.S. and accounts for more than 162,000 deaths in the U.S. each year. Of those people who survive a first stroke, 14% will have another one within a year. Stroke is the number one cause of long-term disability among Americans. Between 50% and 70% of stroke survivors regain functional independence; however 15% to 30% are permanently disabled. Three months after stroke, 20% of survivors require institutional care. According to the American Heart Association, stroke cost was approximately $58 billion in both direct and indirect costs in 2006.

About Arimoclomol

Arimoclomol is one of three CytRx-owned clinical-stage compounds based on its small molecule "molecular chaperone" co-induction technology. Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of "molecular chaperones." Since damaged proteins called aggregates are thought to play a role in many diseases, CytRx believes that activation of molecular chaperones could have therapeutic efficacy for a broad range of diseases.

About CytRx Corporation

CytRx Corporation is a biopharmaceutical research and development company engaged in the development of high-value human therapeutics. The Company owns three clinical-stage compounds based on its small molecule "molecular chaperone" co-induction technology. In September 2006, CytRx announced that arimoclomol was shown
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