Cypher Sirolimus-Eluting Coronary Stent Had Similar Results to,,,Bypass Surgery and Better Outcomes Than Bare Metal Stents in,,,Subgroup Analysis of Diabetic Patients With Multivessel Coronary,,,Disease
BARCELONA, Spain, May 22, 2007 /PRNewswire/ -- A three-year
follow-up subset analysis presented today as a late-breaking
clinical trial at EuroPCR 2007 showed that the CYPHER(R)
Sirolimus-eluting Coronary Stent had results comparable to coronary
artery bypass grafting (CABG or bypass surgery) and better outcomes
than bare metal stents (BMS) in diabetic patients with blockages in
two or more coronary arteries.
The CYPHER(R) Stent results in the diabetic population of the
ARTS II Study showed no significant difference in major adverse
cardiac and cerebrovascular events (MACCE) compared to the CABG arm
of the ARTS I Study (27.7 percent versus 17.7 percent,
respectively; p = 0.10). In addition, the analysis showed that the
CYPHER(R) Stent performed significantly better than the BMS arm of
the ARTS I Study, as 47.3 percent of the patients who received a
BMS experienced a MACCE event after three years (p < 0.001).
These findings are significant as MACCE -- comprised of death,
stroke, myocardial infarction (heart attack) and the need for
repeat revascularization (re-treatment) of the blocked artery --
was the primary endpoint of the ARTS II Study.
Sponsored by Cordis Corporation, the ARTS II Study was designed
to determine whether the clinical and cost-effectiveness outcomes
with the CYPHER(R) Stent in 607 patients with multivessel coronary
disease were non- inferior to the results obtained in the ARTS I
Study, which was conducted in 1997 and included 605 patients
treated with bypass surgery and 600 patients treated with a BMS. In
the diabetic subgroup analysis, investigators compared the findings
for the 159 diabetic patients in the ARTS II Study to those from
the ARTS I Study, which included 96 diabetic patients treated with
bypass surgery and 112 treated with a BMS. The risk profile of the
patients in the ARTS II Study was significantly higher Page: 1 2 3 4 Related medicine technology :1
. Cypher Sirolimus-eluting Coronary Stent Had Similar Results to
Bypass Surgery in Long-Term Study of Patients With Multi-Vessel
Coronary Artery Disease2
. Two-Year Patient Registry Results Support Safety and Efficacy of
Cypher Sirolimus-Eluting Coronary Stent in Real World Uses3
. New Study Suggests Better Patient Outcomes with CYPHER
Sirolimus-Eluting Coronary Stent than with Taxus Stent in
Real-World Clinical Settings4
. New Point-of-Care Methods to Measure Coronary and Cerebrovascular Risk5
. BusinessWeek Article Highlights Promising Breakthrough Treatment
for Advanced Coronary Artery Disease6
. BusinessWeek Article Highlights Promising Breakthrough Treatment
for Advanced Coronary Artery Disease7
. Lipitor Reduced the Risk of Coronary Events by Half and Stroke by
Nearly One-Third in High-Risk Patients with Type 2 Diabetes Who
Experienced a Recent Stroke8
. New Analysis of WHI Data Shows Reduced Levels of Coronary Artery
Calcification, a Predictor of Cardiovascular Events, in Women aged
50-59 taking Estrogen Therapy9
. Positive Results for Second-Generation Taxus Liberte Coronary Stent
System Highlighted in Journal of American College of Cardiology10
. Abbott Announces Positive Nine-Month Results From the Worlds First
Clinical Trial of a Fully Bioabsorbable Drug Eluting Coronary Stent11
. Abbott Announces Continued Positive Results with Xience V
Everolimus Eluting Coronary Stent in Spirit Clinical Trials
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