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Curis Announces Hedgehog and Wnt Antagonist Data Presentation at,AACR

ults in growth delay of a subset of these primary human pancreatic cancer xenografts.

The poster also included data supporting a mechanism whereby some tumors may utilize the Hedgehog pathway to promote their growth by sending signals to the surrounding normal tissue (termed paracrine tumor-stromal hedgehog signaling). These studies suggest that cancers dependent upon such cross-talk between tumors and surrounding normal tissue might respond to the inhibition of the Hedgehog pathway.

In January 2007, Genentech initiated a phase I clinical trial of a systemically administered small molecule Hedgehog antagonist for cancer. The phase I trial is an open-label study in patients with locally advanced or metastatic cancers that are refractory to standard therapy, or for whom no standard therapies exist. The primary objectives of the phase I trial are to evaluate the safety and tolerability of escalating doses of the phase I molecule and to establish the maximum tolerated dose and dose limiting toxicities. The trial is expected to enroll approximately 50 patients spread across several dose-escalating cohorts.

"We are pleased with the recent progress that we've made in our programs under collaboration with Genentech, particularly with the recent initiation of a systemically administered Hedgehog antagonist Phase I clinical trial," said Daniel R. Passeri, President and Chief Executive Officer of Curis. "We believe that the Wnt and Hedgehog data that were presented at AACR continue to demonstrate the depth of the biological and mechanistic understanding of both of these programs and we look forward to further advances in each of the Hedgehog and Wnt programs."

About Curis, Inc.

Curis is a drug development company that is committed to leveraging its innovative signaling pathway drug technologies to create new medicines, primarily for cancer. In expanding its drug development efforts in the field of cancer through its Targeted Cancer Drug Devel
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