Navigation Links
Curis Announces Hedgehog and Wnt Antagonist Data Presentation at,AACR

ults in growth delay of a subset of these primary human pancreatic cancer xenografts.

The poster also included data supporting a mechanism whereby some tumors may utilize the Hedgehog pathway to promote their growth by sending signals to the surrounding normal tissue (termed paracrine tumor-stromal hedgehog signaling). These studies suggest that cancers dependent upon such cross-talk between tumors and surrounding normal tissue might respond to the inhibition of the Hedgehog pathway.

In January 2007, Genentech initiated a phase I clinical trial of a systemically administered small molecule Hedgehog antagonist for cancer. The phase I trial is an open-label study in patients with locally advanced or metastatic cancers that are refractory to standard therapy, or for whom no standard therapies exist. The primary objectives of the phase I trial are to evaluate the safety and tolerability of escalating doses of the phase I molecule and to establish the maximum tolerated dose and dose limiting toxicities. The trial is expected to enroll approximately 50 patients spread across several dose-escalating cohorts.

"We are pleased with the recent progress that we've made in our programs under collaboration with Genentech, particularly with the recent initiation of a systemically administered Hedgehog antagonist Phase I clinical trial," said Daniel R. Passeri, President and Chief Executive Officer of Curis. "We believe that the Wnt and Hedgehog data that were presented at AACR continue to demonstrate the depth of the biological and mechanistic understanding of both of these programs and we look forward to further advances in each of the Hedgehog and Wnt programs."

About Curis, Inc.

Curis is a drug development company that is committed to leveraging its innovative signaling pathway drug technologies to create new medicines, primarily for cancer. In expanding its drug development efforts in the field of cancer through its Targeted Cancer Drug Devel
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
4. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
5. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
11. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
Post Your Comments:
(Date:10/2/2014)... 2, 2014  MJ Freeway®, the industry-leading cannabis business ... detailing upcoming legalization efforts in Oregon ... Nevada .  The success of the measures being ... on the national level. On October 7th, ... the Marijuana Policy Project, an organization dedicated to making ...
(Date:10/2/2014)... , Oct. 2, 2014  Isis Pharmaceuticals, Inc. ... webcast:What: , Webcast and conference call to provide ... clinical studies of ISIS-SMN Rx in infants ... will be presented on the morning (CEST) of ... Muscle Society in Berlin, GermanyWhen:Friday, October 10 at ...
(Date:10/1/2014)... Calif. , Oct. 1, 2014  Abaxis, Inc. ... manufacturing point-of-care instruments and consumables for the medical, research, ... to the veterinary and research markets in ... entered into a definitive distribution agreement with Patterson Veterinary ... and promote the full line of Abaxis veterinary products ...
Breaking Medicine Technology:MJ Freeway to Host Educational Webinars Regarding Crucial Marijuana Legalization Efforts in Alaska, Nevada and Oregon 2Isis Pharmaceuticals to Host Webcast to Discuss ISIS-SMN Rx Results Presented at the World Muscle Society Congress 2Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 2Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 3Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 4
(Date:10/2/2014)... 02, 2014 Originally considered alternative ... is becoming increasingly popular with consumers. This has ... Poultry Farming industry in Australia. According to ... organic meat has surged over the past five ... the farming level.” Over the five years through ...
(Date:10/2/2014)... (HealthDay News) -- Scientists have pinpointed a molecule that ... colds. The researchers say this finding could offer ... treat these attacks. Most asthma attacks (80 percent ... the airways, according to the British researchers. Most of ... the common cold. The researchers found that a ...
(Date:10/2/2014)... Dennis Thompson HealthDay ... A newborn,s risk of developing celiac disease isn,t reduced by ... in wheat called gluten to an infant,s diet help prevent ... pair of new studies in the Oct. 2 New ... to rest hopes that a child could avoid celiac disease ...
(Date:10/2/2014)... University of Nottingham could lead to the development of ... resulting from the research, published in the journal ... sufferers of chronic pain conditions such as traumatic nerve ... , The work, led by Dr Lucy Donaldson in ... David Bates, Professor of Oncology in the University,s Cancer ...
(Date:10/1/2014)... new research study published today in the Journal ... patients older than 50 years with moderate or severe ... , Researchers from the University of Melbourne randomly assigned ... pain to no acupuncture or sham or pretend laser ... with participants and acupuncturists blinded to laser and sham ...
Breaking Medicine News(10 mins):Health News:Organic Livestock and Poultry Farming in Australia Industry Market Research Report Now Available from IBISWorld 2Health News:Organic Livestock and Poultry Farming in Australia Industry Market Research Report Now Available from IBISWorld 3Health News:Organic Livestock and Poultry Farming in Australia Industry Market Research Report Now Available from IBISWorld 4Health News:New Clues to How Colds Can Spur Asthma Attacks 2Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 2Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 3Health News:Medical discovery first step on path to new painkillers 2Health News:Study finds acupuncture does not improve chronic knee pain 2
... 29 LodgeNet Interactive Corporation (Nasdaq: LNET ... offering of 50,000 shares of 10% Series B Cumulative ... liquidation preference of $1,000 per share. In addition, the ... to purchase an additional 7,500 shares of preferred stock ...
... HealthCare System has organized a new business unit ... North and South Carolina. , , The newly ... (SHVI) represents a combination of Sanger Clinic, Charlotte Cardiology Associates ... serving as a regional referral center for highly specialized care. ...
... Clovis Students Win Thousands of Dollars in Milk Contest , ... month after month with Premenstrual Syndrome, a.k.a. man,s worst nightmare. ... whom do not yet know that milk could be the ... effort to educate women on the PMS-fighting benefits of the ...
... ... to share their perspectives on eye care and safety. , ... Minneapolis, MN (PRWEB) June 29, 2009 -- Stop squinting…proper eye ... July,s fireworks displays in all their brilliance and clarity., , , The Healthcare Scoop , ...
... , JACKSONVILLE, Fla., June 29 On June ... the European Association for the Study of Diabetes investigated ... sanofi-aventis) and the development of certain malignancies. The authors ... their limited data and analyses, which precluded them from ...
... most parents of high school and college-age students and they,ll tell ... life,s tough questions. Truth is, at that age they are forming ... their lives. A new initiative, Reach Teach Learn , is ... that honest, educated decisions are made. , , Alpharma Inc., ...
Cached Medicine News:Health News:LodgeNet Interactive Announces Completion of Offering of $57.5 Million of Convertible Preferred Stock 2Health News:LodgeNet Interactive Announces Completion of Offering of $57.5 Million of Convertible Preferred Stock 3Health News:LodgeNet Interactive Announces Completion of Offering of $57.5 Million of Convertible Preferred Stock 4Health News:Sanger Clinic Lends Its Name to New Heart Care Institute Serving NC and SC 2Health News:No More Drama With TOMA LECHE 2Health News:No More Drama With TOMA LECHE 3Health News:No More Drama With TOMA LECHE 4Health News:The Healthcare Scoop Community Says 'Eye Care' 2Health News:The Healthcare Scoop Community Says 'Eye Care' 3Health News:AACE Response to Insulin Glargine Cancer Risk Articles in Diabetologia 2Health News:Alpharma's Reach Teach Learn Initiative Targets Youth and Consumer Awareness 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: