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Curis Announces Hedgehog and Wnt Antagonist Data Presentation at,AACR

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 17, 2007 - Curis, Inc. (NASDAQ:CRIS), a drug development company focused on novel targeted medicines primarily for cancer treatment, today announced that its data was included in two presentations at the 98th Annual Meeting of the American Association for Cancer Research (AACR).

At AACR, Curis also disclosed that its April 2005 discovery collaboration agreement with Genentech focused on developing drug candidates that target the Wnt signaling pathway, particularly for potential cancer indications. Abnormal activation of Wnt signaling is present in various cancers, including colon, breast and ovarian cancers. Developing drug candidates that are designed to inhibit, or antagonize, Wnt signaling could hopefully provide a potential option in certain cancers.

On April 14, data was presented during an Educational Session titled "Targeting the Wnt Pathway in Cancer," which included a discussion of the Curis-Genentech joint effort in the identification of small molecule inhibitors of the Wnt pathway, under the April 2005 discovery collaboration agreement. The parties' research efforts have yielded a class of Wnt antagonists that, in preclinical studies, inhibit the Wnt pathway by acting upstream of beta-catenin, which is believed to be an important molecular target in the Wnt pathway. Inhibiting such an upstream molecular target may represent an attractive approach for potential inhibition of the Wnt pathway in cancer cells with abnormally active Wnt signaling.

In addition to the Educational Session, a poster was also presented at the conference describing the use of Hedgehog antagonists in a preclinical pancreatic tumor model. In these studies, Genentech and Curis scientists used a potent small molecule antagonist of the Hedgehog pathway on mice implanted with primary human pancreatic cancer xenografts. The scientists found that antagonizing the Hedgehog pathway res
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