Navigation Links
Critical Therapeutics Announces the Publication of New Preclincial,HMGB1 Data in Nature Immunology

LEXINGTON, Mass.--(BUSINESS WIRE)--Apr 18, 2007 - Critical Therapeutics, Inc. (Nasdaq: CRTX) today announced that new preclinical research demonstrating a role in chronic inflammatory autoimmune disease for High Mobility Group Box-1 protein (HMGB1), a pro-inflammatory mediator and nuclear DNA-binding protein, will be published in the May 2007 issue of Nature Immunology. The publication demonstrates that HMGB1 is part of DNA complexes that can stimulate immune cells to produce potent inflammatory mediators, which in turn can contribute to the inflammatory pathology of autoimmune disease. The work adds to the growing body of literature regarding the pro-inflammatory activity of HMGB1 and indicates a potentially important role for this protein in chronic inflammatory disease as well as in severe, acute systemic inflammatory disease, such as sepsis.

"The work described in the Nature Immunology article provides important new insight into the mechanism by which HMGB1 exerts pro-inflammatory activity," said Gregory LaRosa, Ph.D., Critical Therapeutics' Vice President of Discovery Research. "The preclinical data suggest that HMGB1 may contribute to the disease pathology of lupus and supplement earlier research suggesting that a therapeutic antibody to HMGB1 may provide protection in chronic inflammatory disease. As we work in collaboration with MedImmune, Inc., to develop monoclonal antibodies (MAbs) directed towards HMGB1, this new information as to how HMGB1 provides a pro-inflammatory stimulus will help guide our efforts."

The collaboration with MedImmune and Critical Therapeutics is working to discover and develop novel therapeutics for both severe, acute inflammation, and for chronic allergic and autoimmune inflammatory diseases. The collaborative HMGB1 therapeutic antibody project is one of the key development efforts at Critical Therapeutics, and with MedImmune, has made progress towards the identificatio
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
3. Critical Therapeutics Announces the Publication of Data for ZyfloCR (Zileuton) Extended-Release Tablets in the Journal of Asthma
4. New Critical Path Report Highlights Research Needed to Foster Generic Drug Development
5. Data Show SuperGens Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51
6. MIV Therapeutics Announces Pivotal Test Results Further Validating Company Stent Coatings Meet Critical FDA Fatigue Guidelines
7. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
8. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
9. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
10. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
11. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
Post Your Comments:
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, suppliers and distributors ... able to protect their most important business assets, ... ) Because of the highly-competitive ... remains one of the most litigious industry sectors ...
(Date:1/15/2014)... , Jan. 15, 2014 MultiCell Technologies, Inc. ... a U.S. provisional patent application concerning composition of matter, ... achieve targeted tumor cell death.  This ... noncoding double stranded RNA molecules (VSRNAs) which interfere with ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Intellectual Property Insurance for Medical-related Products and Services 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
... Hill-Rom Holdings, Inc., (NYSE: HRC ) invites you to listen to a ... the Goldman Sachs 31st Annual Global Health Care Conference in Los Angeles ... 10:40 a.m. PDT ).     , , ... invited to listen to the live discussion via the internet link at http://ir.hill-rom.com/events.cfm ...
... June 2 Today In the Face of ... help pain management advocates expand their outreach efforts through popular ... to social media applications, such as Facebook, and walks users ... communication vehicles. Topics include "An Overview of Social Media," "Advocacy ...
Cached Medicine Technology:Hill-Rom to Participate at the Goldman Sachs 31st Annual Global Health Care Conference 2In the Face of PainĀ® Offers Social Media 101 for Pain Management Advocates 2
(Date:4/17/2014)... EcoHealth Alliance, a nonprofit organization that focuses on ... review today examining the current state of knowledge of ... for improved global surveillance strategies to combat the emergence ... Ebola in West Africa that has claimed the lives ... Liberia. According to the World Health Organization (WHO), ...
(Date:4/17/2014)... team led by Cesar A. Arias, M.D., Ph.D., at ... (UTHealth) has identified a new superbug that caused a ... in the April 17 issue of The New ... is part of a class of highly-resistant bacteria known ... is a major cause of hospital and community-associated infections. ...
(Date:4/17/2014)... April 17, 2014 Meaningful long-term survival is ... of the abdomen when treated with cytoreductive surgery ... a first-of-its-size analysis by physicians at Wake Forest ... the largest reported, single-center experience with cytoreductive surgery ... M.D., and analysis of 20 years, worth of ...
(Date:4/17/2014)... shocking rates of suicide are highest in areas with ... smallholdings less than one hectare and trying ... that are highly susceptible to global price fluctuations. , ... that point to a crisis in key areas of ... economy during the 90s. Researchers say that policy intervention ...
(Date:4/17/2014)... Vice-Chancellor, Professor Patrick Johnston, whose work has transformed cancer ... Fellow of the European Academy of Cancer Sciences., The ... advisory body of highly distinguished oncologists and cancer researchers ... by cancer in Europe. , Professor Johnston, whose leadership ... from the bottom of the UK league table to ...
Breaking Medicine News(10 mins):Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:New MRSA superbug emerges in Brazil 2Health News:20 years of data shows treatment technique improvement for advanced abdominal cancer 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 3
... ways of taking care your medication. Sometimes half a pill does ... off a medication, or be given a double dose of a ... pill into two or more doses. ,Doctors at the ... pill splitting. First, you need to check if your pill is ...
... that, everyone should be aware of the dangers of ... the body over-reacts to an infection. It often follows ... can attack anyone.// In fact sepsis claims more lives ... is the leading cause of death in intensive care. ...
... Specific exercises to strengthen the back have been found ... after the menopause and involves a reduction in bone ... bone fractures. Doctors at the University of Atlanta, now ... very effective in reducing this fracture risk. ...
... According to a recent study, a combined scan identifies unstable ... of heart attack in the future. Fatty deposits, known as ... of plaque - atherosclerosis - begins many years before any ... crack, instigating formation of a clot which will then cause ...
... recent study, a simple imaging test may identify patients ... heart condition. Researchers used Doppler tissue imaging (DTI) as ... in a patient's life.// Hypertrophic cardiomyopathy (HCM) causes thickening ... the most common cause of sudden cardiac death in ...
... parts of Australia suggest that the healthy limit on body ... mass index (BMI) is calculated by dividing your mass in ... BMI between 20-25 was considered to be the healthy range, ... Health risks increase with BMI over 25. But a survey ...
Cached Medicine News:
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: