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Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at ESMO Conference

>In the 38 patients who were evaluable in the Phase I/II trial, 33 patients (87%) experienced a decline in prostate specific antigen (PSA) levels with 23 patients (61%) experiencing a confirmed decline in PSA levels of greater than 50%, and with 10 of the 38 patients (26%) experiencing PSA declines of greater than 90%. Of the 20 evaluable patients with measurable tumor lesions, treatment with CB7630 resulted in partial radiological responses (as measured by the RECIST criteria) in 11 patients (55%), with 7 patients demonstrating ongoing stable disease and 3 patients experienced regressing bone disease. Individual patients treated with CB7630 also experienced improvement in pain and a reduction in opioid use.

Currently 21 of the 38 patients (55%) in the Phase I/II trial remain on study and are continuing to be treated with CB7630. For the 38 evaluable patients in the trial, the median time to PSA progression has not been reached and is currently estimated to be 252 days (8.4 months).

Abiraterone, an oral, irreversible CYP450c17 enzyme inhibitor appears to have activity in post-docetaxel castration resistant prostate cancer

The Phase II trial of CB7630 in patients with advanced prostate cancer who have failed docetaxel-based chemotherapy is being conducted at numerous locations in the United States and United Kingdom. In the trial, CB7630 is administered orally, once daily, to patients with castration resistant prostate cancer who have failed treatment with androgen deprivation therapy and failed treatment with first line docetaxel-based chemotherapy. To date, a total of 43 patients have been enrolled in the trial.

In his poster and oral presentation, Dr. Gerhardt Attard from The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust in the United Kingdom provided an update on the 30 patients in this Phase II trial who have been treated in the United Kingdom. Of these 30 patients, all of the patients had failed treatment wi
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