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Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting

surable tumor lesions, treatment with CB7630 resulted in partial radiological responses (as measured by the RECIST criteria) in 11 patients (55%), with 7 patients demonstrating ongoing stable disease and 3 patients experienced regressing bone disease. Individual patients treated with CB7630 also experienced improvement in pain and a reduction in opioid use.

Currently 19 (63%) of the 30 patients in the Phase I/II trial remain on study and are continuing to be treated with CB7630. Of the 15 patients in the Phase I portion of the trial, 9 patients (60%) are still receiving treatment with CB7630, with the average patient having received the drug for over 9.2 months and with 4 patients having received the drug for over 12 months.

Dr. Arie S. Belldegrun, M.D., FACS, Vice Chairman of the Board of Directors of Cougar Biotechnology, said, "The clinical data on abiraterone continues to demonstrate strong evidence of the antitumor activity of the drug in CRPC patients. CB7630 has the potential to be used by both urologists who treat patients with second line hormonal therapies and by medical oncologists who treat patients in the second line chemotherapy setting; therefore, we are pleased to be able to present, for the first time, the clinical data on abiraterone to the urology community." Alan H. Auerbach, Chief Executive Officer and President of Cougar Biotechnology, added, "We are pleased to be able to present the clinical data from this CB7630 trial at AUA. We look forward to continuing to provide updates on these ongoing trials at future cancer conferences and greatly look forward to the continued development of CB7630 in both the second line hormone therapy and second line chemotherapy settings."

About Cougar Biotechnology

Cougar Biotechnology, Inc. is a Los Angeles-based biotechnology company established to in-license and develop clinical stage drugs, with a specific focus on the field of oncology. Cougar's oncology portfolio includes CB7630,
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