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Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting

LOS ANGELES--(BUSINESS WIRE)--May 21, 2007 - Cougar Biotechnology, Inc. (OTCBB:CGRB) today announced that positive Phase I and Phase II data on the Company's prostate cancer drug candidate CB7630 (abiraterone acetate) was presented at the American Urological Association (AUA) Annual Meeting, which is currently taking place in Anaheim, California. The data was presented by Dr. Timothy A. Yap from the Cancer Research UK Centre for Cancer Therapeutics at The Institute of Cancer Research in an oral presentation entitled, "Abiraterone acetate, an inhibitor of androgen synthesis, has significant antitumor activity in castration resistant prostate cancer."

The Phase I/II trial of CB7630 was conducted at The Institute of Cancer Research and at The Royal Marsden NHS Foundation Trust in the United Kingdom. In the trial, CB7630 was administered orally, once daily, to chemotherapy-naive patients with castration refractory prostate cancer (CRPC), who had progressive disease despite treatment with LHRH analogues and multiple other hormonal therapies, including antiandrogens, diethylstilboestrol and dexamethasone. To date a total of 38 patients have been treated in the Phase I/II trial, including 15 patients treated in the Phase I portion of the trial and 23 patients treated in the Phase II portion of the trial. In his presentation, Dr. Yap reported that in the 38 patients treated in this trial, CB7630 was well tolerated at doses as high as 2000 mg/day with minimal toxicity. Moreover, no dose limiting toxicity has been observed in the trial to date.

In the 30 patients who were evaluable in the Phase I/II trial, 18 patients (60%) experienced a confirmed decline in prostate specific antigen (PSA) levels of greater than 50%, with 10 of the 30 patients (33%) experiencing PSA declines of greater than 90%. Six additional patients (20%) experienced a decline in PSA that was less than 50%. Of the 20 evaluable patients with mea
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