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Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at ASCO Annual Meeting

LOS ANGELES--(BUSINESS WIRE)--Jun 4, 2007 - Cougar Biotechnology, Inc. (OTCBB: CGRB) today announced that positive interim Phase I and Phase II data on the Company's prostate cancer drug candidate CB7630 (abiraterone acetate) was presented at the American Society of Clinical Oncology (ASCO) Annual Meeting, which is currently taking place in Chicago, Illinois. The data was presented in two poster presentations on Saturday, June 2nd, as part of the poster discussion session for genitourinary (prostate) cancer that took place. The poster presentations are further detailed below:

Phase I/II Study of Continuous Oral Dosing of an Irreversible CYP17 Inhibitor, Abiraterone, in Castration-Resistant Prostate Cancer Patients Incorporating the Evaluation of Androgens and Steroid Metabolites in Plasma and Tumor and the Study of Circulating Tumor Cells

The Phase I/II trial of CB7630 was conducted at The Institute of Cancer Research and at The Royal Marsden NHS Foundation Trust in the United Kingdom. In the trial, CB7630 was administered orally, once daily, to chemotherapy-naive patients with castration resistant prostate cancer (CRPC), who had progressive disease despite treatment with LHRH analogues and multiple other hormonal therapies, including antiandrogens, diethylstilboestrol and dexamethasone. To date, a total of 42 patients have been treated in the Phase I/II trial, including 15 patients treated in the Phase I stage of the trial and 27 patients treated in the Phase II stage of the trial. In his poster presentation, Dr. Gerhardt Attard from The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust in the United Kingdom reported that in the 42 patients treated in this trial, CB7630 was well tolerated at doses as high as 2000 mg/day with minimal toxicity. Moreover, no dose limiting toxicity has been observed in the trial to date.

In the 34 patients who were evaluable for response in the
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