Navigation Links
Corcept Therapeutics Announces Phase 3 Study Evaluating Corlux for,Psychotic Major Depression Misses Primary Endpoint

consin, said “The correlation between plasma levels of drug and response rates found in this trial is very exciting. The results of this study show that when psychotically depressed patients achieve a threshold concentration of CORLUX in their system, a rapid and sustained clinical response is likely. This is a strong demonstration of a drug effect in an illness that is potentially devastating and difficult to treat.” Dr. Kalin is a member of Corcept’s Scientific Advisory Board.

Next Phase 3 Clinical Trial Being Planned

Robert L. Roe, M.D., Corcept’s President said, “We believe that the confirmation of a drug concentration threshold for efficacy as well as other observations from Study 06 and the company’s two recently completed Phase 3 clinical trials will serve as a strong basis for the company’s next Phase 3 study. In the upcoming trial which is planned to commence later in 2007, we expect to use a dose level of 1200 mg once per day for seven days because, in Study 06, 80% of the patients achieved a drug plasma level sufficient for a strong clinical response at that dose. In our initial review of a summary of the safety data, we have seen no difference between any of the dose levels used in Study 06. We believe that this change in dose as well as other modifications to the protocol should allow us to definitively demonstrate the efficacy of CORLUX in the treatment of the psychotic features of PMD.”

About Study 06

Study 06 was a randomized, double-blind, placebo-controlled study in which 443 patients were enrolled at 45 sites in the United States and Europe. The primary endpoint, a responder analysis, was the proportion of patients with at least a 50 percent improvement in the Brief Psychiatric Rating Scale Positive Symptom Subscale (BPRS PSS) at both Day 7 and Day 56. Specifically, the BPRS is an 18-item rating instrument used to assess psychopathology, and the PSS is a subset of four ite
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
5. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
6. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
7. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
8. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
9. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
10. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
11. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
Post Your Comments:
(Date:9/2/2015)... , Sept. 2, 2015 Research ... addition of the "Medical Device Studies: Clinical ... conference to their offering. This ... are involved in gathering clinical evidence required for ... is required for all medical devices and the ...
(Date:9/2/2015)... DUBLIN , Sept. 2, 2015 Research ... of the "New EU Pharmacovigilance Legislation (London, UK ... The 15 new EU modules concerning ... way Pharmacovigilance is conducted in Europe ... at these modules and their requirements, examine how they ...
(Date:9/2/2015)... Sept. 2, 2015 Demers Ambulances is proud to ... their new dealer for the states of Mississippi ... Tennessee . "This will enable Demers ... Benoit Lafortune , Executive Vice-President for Demers Ambulances. "Emergency Equipment ... and Alabama , giving them ...
Breaking Medicine Technology:Medical Device Studies: Clinical Evidence Course - London, UK - November 10-11, 2015 2Demers Ambulances has named Emergency Equipment Professionals (EEP) Inc. as their dealer for the states of MS, AL and TN 2
(Date:9/3/2015)... ... 03, 2015 , ... DiabetesSisters Welcomes Carol Wysham to Board ... of Carol Wysham, MD, to their esteemed Board of Directors. Dr. Wysham was ... Warren, Matt Stella, Tricia Cedotal, Andrea Thomas, Wanda Nicholson and Vicki Norris. As ...
(Date:9/3/2015)... ... ... A scar is an unavoidable result of incision or injury to the skin. Unsightly as ... itself. The appearance of a scar is dependent on many factors – the size and ... scars fade to near invisibility on their own over a period of months,” says ...
(Date:9/3/2015)... ... 03, 2015 , ... The new In-Office whitening kit from ... The Clinicians Report is a leading information source to the dental industry. Product ... Whiter Image's In-Office whitening kits were favorably validated for use in the dental ...
(Date:9/3/2015)... ... September 03, 2015 , ... James Earl Jones will be ... In this episode, James Earl Jones will introduce a segment that discusses why it ... and how workplace wellness can be fostered in any working environment. , Employers are ...
(Date:9/2/2015)... ... September 03, 2015 , ... The Aspen Clinic (TAC), located in ... towards kick-starting and inspiring wellness in the Roaring Fork Valley and beyond. , Amanda ... whole mind-body approach to fitness - we are much more than a gym. ...
Breaking Medicine News(10 mins):Health News:Carol H. Wysham, MD, Joins DiabetesSisters Board of Directors 2Health News:Do I Have To Live With That Scar? 2Health News:Do I Have To Live With That Scar? 3Health News:Do I Have To Live With That Scar? 4Health News:Whiter Image Products Get Positive Rating From The Clinicians Report 2Health News:James Earl Jones Hosts a New "Voices In America" Piece on Making the Workplace Healthier 2Health News:TAC Introduces New Retreats for Fall Fitness 2
... , ... announces that their Electronic Health Record, Perfect Care EHR® ... Information Technology (CCHIT®) and is Preliminary ARRA 2011 certified, ... Use Objectives for Eligible Providers under the American Recovery ...
... drug cocktail might be the right mix to fight ... Details of a new study supporting this approach suggest ... work again. The findings were presented today at the ... involves post-menopausal women whose advanced breast cancers are fueled ...
... that could prevent another blood clot, study finds , ... stroke survivors don,t take medications that can reduce their risk ... stroke is caused by blocked blood flow in the brain. ... ischemic stroke. These include blood thinners (antithrombotic medications), of which ...
... , , , WINSTON-SALEM, N.C., Dec. 11 ... officers once again put the spotlight on mass murder in ... killings at Fort Hood, the Washington case raised questions about ... rampage. , Andrew Smiler, an assistant professor of psychology at ...
... , DALLAS, Dec. 11 For their ... rehabilitation for younger, more active cardiac patients, the Cardiac ... Heart and Vascular Hospital was recently awarded the Innovation ... Rehabilitation (AACVPR). The award acknowledges programs that have enhanced ...
... survey respondents were under 35 when they sought treatment , ... that age is an important factor in the success of ... 18 and older, including 125 women who,ve had fertility treatment. ... were under age 35 when they first sought medical advice ...
Cached Medicine News:Health News:NCG Medical, Perfect Care EHR Achieves Preliminary ARRA 2011 Certification From CCHIT 2Health News:NCG Medical, Perfect Care EHR Achieves Preliminary ARRA 2011 Certification From CCHIT 3Health News:Clinical trial advances new approach to re-sensitizing breast cancer 2Health News:Mass Murderers: Why Do They Kill? 2Health News:Baylor Hamilton Heart Hospital Honored for Innovative Rehabilitation Program 2Health News:Baylor Hamilton Heart Hospital Honored for Innovative Rehabilitation Program 3Health News:Women Aren't Waiting to Seek Infertility Help 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: