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CombinatoRx to Present Combination High Throughput Screening (cHTS),Data at Upcoming AACR Meeting

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 12, 2007 - CombinatoRx, Incorporated (NASDAQ: CRXX), today announced that posters related to its oncology research efforts will be presented at the 98th Annual Meeting of the American Association for Cancer Research, April 14-18, 2007 in Los Angeles, CA.

"Systematic Screening of Targeted Chemical Combinations for Cancer Therapy", Heilbut, et.al. (Abstract #1410) will be presented on Sunday, April 15, 1-5pm PT and "Synergistic Enhancers of TRAIL-Mediated Apoptosis: A Quantitative Parallel Comparison of TRAIL-Small Molecule Synergies using cHTS(TM)", Short, et.al. (Abstract #4873) will be presented on Tuesday, April 17, 1-5pm PT.

About cHTS(TM)

To discover combinations of molecules that exhibit novel patterns of activity against disease networks, CombinatoRx, Incorporated uses its combination High Throughput Screening (cHTS(TM)) drug discovery platform. Using this proprietary platform, the company systematically searches millions of combinations across a large portfolio of phenotypic disease models, identifying patterns of activity against both known and novel targets in a broad range of disease areas. Each combination is evaluated to quantify and visualize its activity at a range of dose ratios. Combinations with synergistic therapeutic effects against disease phenotypes are flagged automatically using a custom-designed informatics backbone, then profiled to further determine their mechanism of action and product suitability. Innovations in computational biology techniques and software design automate the CombinatoRx process, enabling the company to search large numbers of combinations and rapidly select candidates with desirable patterns of activity.

About CombinatoRx

CombinatoRx, Incorporated (CRXX) is pioneering the new field of synergistic combination pharmaceuticals and has a broad product portfolio in phase 2 clinical development. Going bey
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