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CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and,Pain, but Not CRP

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 28, 2007 - CombinatoRx, Incorporated (NASDAQ: CRXX) today announced preliminary results of its randomized, blinded, placebo-controlled clinical trial of CRx-150 in patients with rheumatoid arthritis (RA). The trial compared CRx-150 plus a disease-modifying anti-rheumatic drug (DMARD) to placebo plus DMARD (control) in subjects with active RA. In the preliminary analysis of this trial, CRx-150 demonstrated statistically significant effects on DAS28 and pain, a trend on ACR20 and no effect on CRP. -0-
Measure       Regimen     ITT Population    PP Population

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DAS28(a)          CRx-150   -0.51 (p=0.05)    -0.73 (p=0.07)

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                  Placebo           -0.05             -0.11

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ACR20             CRx-150     27% (p=0.13)      37% (p=0.08)

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                  Placebo              11%               13%

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CRP(a)            CRx-150       +0.25mg/L           -0.5mg/L

                                  (p=0.34)          (p=0.48)

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                  Placebo        -0.25mg/L          -0.2mg/L

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(a) Data provided are median change from baseline to day 42.

For CRx-150 treated subjects, median baseline pain as measured on a visual analogue scale (VAS), went from 63.0mm to 37.0mm at day 42, with a median change of -11.5mm, whereas placebo went from 64.5mm at baseline to 59.5mm at day 42, with a median change of -2.0mm (p=0.04).

CRx-150 was generally well tolerated. The most common adverse events in the CRx-150-treated group included headache,
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