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Clinical Update - Debio 9902 (ZT-1) for Alzheimer's Disease

atient compliance and efficacy," said David Wilkinson, MARC, Moorgreen Hospital, Southampton, England and Principal Investigator in the United Kingdom.

About 'BRAINz'

'BRAINz' (Better Recollection for Alzheimer's patients with ImplaNts of ZT-1) is a phase II, double blind, double dummy clinical trial with Debio 9902 SR. The study will measure the safety and efficacy of Debio 9902 SR implants, in comparison to oral donepezil. The 'BRAINz' study is registered on www.clinicaltrials.gov.

About Debio 9902

Debio 9902 is a novel acetylcholinesterase (AchE) inhibitor that is transformed non-enzymatically into its active compound: Hup A. Hup A has been used in China for centuries to treat distinct disorders such as memory loss, schizophrenia and hypertension, and is widely used in North America and Europe as a food additive to enhance cognition and neuroprotection. The dual mode of action of Debio 9902 as an N-methyl-D-aspartate receptor antagonist and an AChE inhibitor, positions it as a third generation anti-Alzheimer's product by improving the general condition and cognitive functions of affected patients as well as having the potential of being a neuroprotectant. A compound with neuroprotective properties to complement the cholinergic effect, could potentially reduce the progression of AD. Debiopharm is seeking a partner for further development and commercialisation of Debio 9902.

About Debiopharm Group

Debiopharm Group is a global biopharmaceutical development specialist that in-licenses promising biologics and small molecule drug candidates. Debiopharm develops its products for global registration and maximum commercial potential for out-licensing to pharmaceutical partners for sales and marketing.

Debiopharm independently funds the worldwide development of all of its products while providing expertise in pre-clinical and clinical trials, manufacturing, drug
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