Navigation Links
Clinical Update - Debio 9902 (ZT-1) for Alzheimer's Disease

Presentation of Final Phase I Monthly Implant and Phase IIa Daily Oral Results

LAUSANNE, Switzerland, June 11, 2007 /PRNewswire/ -- Debiopharm Group (Debiopharm), a global independent biopharmaceutical development specialist in oncology and serious medical conditions, presented final results of two Debio 9902 (formerly ZT-1) studies for the treatment of Alzheimer's disease (AD) at the Alzheimer's Association International Conference on the Prevention of Dementia, in Washington, DC:

- The phase I monthly sustained release implant study showed that Debio 9902 was well tolerated after repeated doses up to 15mg/per month and there were no safety concerns.

- The phase IIa once-daily oral study for a treatment period of 9 months showed that Debio 9902 was safe and effective in the treatment of moderate AD.

In a phase I study, healthy volunteers were administered once monthly subcutaneous injections of Debio 9902 SR implants up to 15mg. Sustained levels of Huperzine A (Hup A), the active metabolite of Debio 9902, were observed up to four weeks and Debio 9902 was well tolerated.

In a phase IIa study with the oral formulation of Debio 9902 in mild to moderate AD patients, improvements were observed on 3 efficacy scales, the assessment cognitive sub-scale (ADAS-cog), the Mini mental state examination (MMSE) and the Neuropsychiatric inventory questionnaire (NPI-Q). The study included a randomized part which lasted 3 months and which was followed by an additional 6 month open label part. The efficacy shown with the oral formulation, the good safety profile and the sustained release of Debio 9902 implants over one month have led to an ongoing phase II 'BRAINz' study in AD patients.

"The continuous release of Debio 9902 SR implants provides a new treatment alternative with the potential for better tolerance through a progressive, steady release of the active compound, therefore increasing p
'"/>




Page: 1 2 3

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clinical Update Debio for Alzheimer Disease
(Date:5/22/2015)... , May 22, 2015  The U.S. Food ... (filgrastim-sndz) -- the first biosimilar product approved in ... points toward growth in the contract manufacturing organization ... CMO industry is geared to the production of ... major biopharmaceutical products. The healthcare market research publisher,s ...
(Date:5/22/2015)... May 22, 2015  The Mesothelioma Victims Center ... of mesothelioma get the best possible compensation, and they ... with this rare cancer caused by exposure to ... information related to treatment options such as a ... the Mesothelioma Victims Center anytime at 866-714-6466. ...
(Date:5/22/2015)... 2015   InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" ... ("EPS"), today announced that its CGuard TM Embolic Prevention ... Prof. Piotr Musialek , at the EuroPCR ... . PARADIGM, an investigator-initiated P rospective ... roti D revascularization I n symptomatic and increased-risk ...
Breaking Medicine Technology:Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 2Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 3Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
(Date:5/26/2015)... Javon Bea President and CEO Mercy ... her quality improvement and organizational development expertise in ... leadership and direction for the financial, budget, marketing and ... Care and Mercy Durable Medical Equipment. , Denise has ... the last 20 in home care administration. In addition ...
(Date:5/26/2015)... 26, 2015 The professionals from Marietta ... it again, helping local rescue pets with a parking ... dentists, Kirk Kimmerling DDS, Suzanna Aguilera DMD and Garrick ... DVM donating 100% of proceeds from the extravaganza. , ... parking lot to help save unwanted, local animals. ...
(Date:5/25/2015)... 2015 Author Vincent N. Cefalu, Sr., MD. ... are overweight, and many of them aren’t aware of many ... that most people don’t realize the dangers of physical inactivity ... toxins that exist. There is also the fact ... serious tobacco is.” , In “ A Doctor’s Prescription for ...
(Date:5/25/2015)... World Patent Marketing, a vertically integrated ... a home patent that aims to protect both people ... fires cost the United States a total of $11.7 ... Director of World Patent Marketing . "More than ... have no alarmed protection. With the use of fire ...
(Date:5/25/2015)... (PRWEB) May 25, 2015 A recent report ... states 1,000 persons have died as a direct result of ... This marks a 33% rise in overdose deaths attributed to ... Baker, “This issue doesn’t care about geography. This issue doesn’t ... issue doesn’t care about class.” As the state of Mass. ...
Breaking Medicine News(10 mins):Health News:"Rescue Animal Cookout" Announced at Verde Pointe Professional Park on June 25, 2015 2Health News:New Book Reveals ‘A Doctor’s Prescription for Longevity and Survival’ 2Health News:New Book Reveals ‘A Doctor’s Prescription for Longevity and Survival’ 3Health News:Home Maintenance Causes House Fires? World Patent Marketing Introduces the Best Home Patent to Prevent Fire Accidents 2Health News:Home Maintenance Causes House Fires? World Patent Marketing Introduces the Best Home Patent to Prevent Fire Accidents 3Health News:Opioid Deaths Increase by 33 Percent Since 2012 in Mass. 2
... ... and Danone share the leading position in the European Union’s “Novel Foods” category , ... Provo, UT (Vocus) April 28, 2010 ... the European Commission on Food Safety. Now, not only do noni juice and noni leaf ...
... ... in Beverly Hills may hardly qualify as news, except if the girls in the salon chair ... weeks in advance. , ... April 28, 2010 -- On May 16, 2010, at the Tipperary Hair Salon in Beverly Hills, ...
... ... than a month after opening. , ... New York (PRWEB) April 28, 2010 -- Playtime is over at the $800,000 Brooklyn ... opened, the much-anticipated playground was declared a danger to children in order to avoid personal ...
... Mother,s ... chocolates and clothing and get her a therapeutic massage instead. Massage Envy is ... ... you really care. Get the best present for Mother’s Day 2010, a Massage Envy gift ...
... ... healthcare providers, , ... (PRWEB) April 28, 2010 -- The Kramer Group (TKG), a leading provider of quality ... name change was announced today at the opening of the company’s third annual User’s Forum. ...
... , This release is available in <A ... PLoS Medicine we continue our series on Global ... SARS epidemic was a "watershed" for China,s engagement in ... from the University of Technology Sydney and colleagues from ...
Cached Medicine News:Health News:Third European Novel Food Approval Received by Tahitian Noni International 2Health News:Pediatric Patients and Siblings Enjoy Beverly Hills Beauty Makeover 2Health News:Pediatric Patients and Siblings Enjoy Beverly Hills Beauty Makeover 3Health News:New York Personal Injury Lawyer, David Perecman, says New Playground is No Place for Kids 2Health News:New York Personal Injury Lawyer, David Perecman, says New Playground is No Place for Kids 3Health News:Forget the Flowers for Mother's Day This Year -- Get Her a Massage Instead 2Health News:The Kramer Group Completes Strategic Name Change to Kramer Healthcare Technologies 2Health News:Did SARS make China a more global player? 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: