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Clinical Trial Data (Phase 2a) Regarding Inhaled Amikacin Will Be,Presented at American Thoracic Society International Conference

SAN FRANCISCO--(BUSINESS WIRE)--May 9, 2007 - Results of a Phase 2a clinical trial evaluating the potential of NKTR-061 (inhaled amikacin) to treat hospital acquired gram-negative bacterial pneumonia will be presented at the American Thoracic Society (ATS) International Conference, May 18 - 23, 2007, in San Francisco.
WHO:      Dr. Michael S. Niederman, MD, Chairman, Department of

          Medicine, Winthrop-University Hospital, Professor of

          Medicine; Vice Chairman, Department of Medicine, SUNY at


          Dr. Jean Chastre, Professor of Medicine, University of


WHAT:     Four posters detailing the results of a Phase 2a clinical

          trial evaluating the pharmacokinetic, serum and tracheal

          aspirate concentration, safety and antibiotic reduction

          properties of NKTR-061.

          Data will be presented and discussed at this ATS session to

          show a reduction in the use of IV antibiotics in

          mechanically ventilated patients during treatment of

          gram-negative pneumonia with NKTR-061.  Further, the data

          indicate that the administration of NKTR-061 resulted in

          high tracheal aspirate concentrations and high epithelial

          lining fluid concentrations of amikacin in gram-negative

          pneumonia in intubated mechanically ventilated patients.

          Finally, data will be presented indicating that NKTR-061

          achieves safe serum concentrations following multiple

          dosing in intubated mechanically ventilated patients with

          gram-negative pneumonia.

WHEN:     Monday, May 21st, 2007, 8:15-11:00 am (PT)

WHERE:    The American Thoracic Society (ATS) International Conference

          at the San Francisco Marriott Hotel.


NKTR-061 (inhaled amikacin) is being tested to evaluate the safety and tolerability of amikac

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