Navigation Links
Clinical Results From EntreMed's Panzem NCD and Taxol Breast Cancer,Study Presented at ASCO

Safety, Efficacy and Markers Demonstrated in Combination Trial

ROCKVILLE, Md., June 06, 2007 /PRNewswire-FirstCall/ -- EntreMed, Inc. , a clinical-stage pharmaceutical company developing therapeutics primarily for the treatment of cancer and inflammatory diseases, announced the presentation of interim data from the Phase 1b study with Panzem(R) NCD (2ME2 or 2-methoxyestradiol) in combination with Taxol(R) (paclitaxel) in patients with metastatic breast cancer. The study is being conducted at the Duke University Medical Center under a grant from the Susan G. Komen Breast Cancer Foundation. Kimberly L. Blackwell, M.D., Director, Clinical Trials in Breast Cancer at the Duke University Medical Center, and principal investigator presented the data during a podium presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting this week in Chicago, Illinois.

The primary objective of the study was to evaluate the effects of standard chemotherapy (paclitaxel) alone and in combination with the antiangiogenic drug, 2-methoxyestradiol, on biomarkers of hypoxia and angiogenesis in metastatic breast cancer. Prior preclinical studies conducted by the Duke team demonstrated that inhibition of HIF-1alpha (hypoxia-inducible factor-1 alpha) caused near-complete destruction of tumor vessels and significantly improved radio-sensitivity in radiation resistant breast tumors. The inhibition of HIF-1alpha was thought to have the same or similar impact on chemotherapy-resistant tumors. HIF-1alpha is over-expressed in more than 70% of human tumors and HIF-1alpha over-expression correlates with tumor aggressiveness, metastases and poor prognosis.

Results were presented for ten patients with clinical stage IV or inoperable stage III breast cancer who received orally-administered Panzem(R) NCD in combination with Taxol(R). All ten patients received prior anthracycline therapy and nine received taxane therapy.
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
(Date:12/24/2014)... -- Echo Therapeutics, Inc. (NASDAQ: ECTE ... permeation, continuous glucose monitoring and associated technologies, today ... been appointed Chief Executive Officer effective December 22, ... of experience in the medical device, pharmaceutical and ... Vice President, Business Development, Otsuka Pharmaceuticals as well as ...
(Date:12/24/2014)... Dec. 23, 2014 ResMed (NYSE: RMD ... action against Chinese medical device manufacturer BMC Medical Co., Ltd. ... that BMC,s masks listed below infringe ResMed,s patents, and entered ... masks in the United States : ... mask , Willow nasal pillows mask , iVolve ...
(Date:12/24/2014)... Mass. , Dec. 23, 2014   ... ), a biopharmaceutical company developing therapeutic products for ... Medicines Agency (EMA) of the Marketing Authorization Application ... EMA recently granted the company,s request for accelerated ... EMA,s regulatory review time.   The ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... 29, 2012   CSL Behring today announced that the ... review its Biologics License Application (BLA) for a human 4-factor ... K-antagonist therapy (i.e., warfarin) in patients with acute major bleeding. ... would be the first agent of its kind available in ...
... ROBLES, Calif., May 29, 2012 Specialty Silicone ... to the medical device community, inaugurated its state-of-the-art ... Designed for greater efficiency, the facility joins all ... roof, complementing existing facilities in Tustin, Calif. and ...
Cached Medicine Technology:CSL Behring Announces FDA Filing of Biologics License Application for 4-Factor PCC for Urgent Reversal of Vitamin K Antagonist Anticoagulant Therapy 2CSL Behring Announces FDA Filing of Biologics License Application for 4-Factor PCC for Urgent Reversal of Vitamin K Antagonist Anticoagulant Therapy 3Specialty Silicone Fabricators Inaugurates New State-of-the-Art Facility in Paso Robles 2
(Date:12/25/2014)... Recently, BellasDress has launched its ... dresses. BellasDress has chosen their best-selling lace wedding dresses, ... the holiday season. , Now, BellasDress.com features popular ... here at discount prices. The business hopes everyone can ... , “All our elegant products are made ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping ... of the models at LunaDress.co.uk come with big discounts, up to ... veil can turn out to be a most exciting memory and ... always bring surprise to a wedding. On the updated fashion blog, ... veils for a big day . , Going out with friends ...
(Date:12/25/2014)... (HealthDay News) -- The risk of burns from fires ... need to be extra cautious, an expert says. ... significant increase in patients coming in with burns," said ... Volunteer Firefighters Burn Center of Stony Brook University Hospital ... of joy, but if not careful, could quickly turn ...
(Date:12/25/2014)... (HealthDay News) -- Among early stage breast cancer patients ... of one percent will eventually develop leukemia as a ... The finding comes from a review of more than ... and it suggests that the risk for developing treatment-related ... previously thought. "The frequency of bone marrow cancers ...
Breaking Medicine News(10 mins):Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... Players for the NFL,s,Chicago Bears will visit hospitalized ... Chicago VA medical center, as part of the Disabled,American ... McKie and running back Adrian Peterson are,scheduled to visit ... serving,our nation by signing autographs, presenting patients with souvenirs ...
... Health System are testing if vitamins A, C ... ANN ARBOR, Mich., Nov. 10 About ... from troops returning from war to,students with music ... hearing loss., The rising trend is something ...
... Recently issued study that found retail pharmacy workers are ... airborne pharmaceutical agents needs further review -, ... a statement today regarding serious concerns about efforts,by McKesson/Parata ... workers face when they work in pharmacies using air,pressure ...
... in aftermath of earthquake, WASHINGTON, Nov. 10 ... the People,s Republic of China in providing,measles vaccines ... control activities and strengthening the delivery of routine,immunization ... Sichuan --,areas severely impacted by the 8.0 magnitude ...
... Modern Warfare Fight For,Faster Benefit Decisions And Interim ... two groups,representing thousands of American veterans, Vietnam Veterans ... announced that they have filed,a lawsuit against the ... filed in the United States District Court for ...
... Tomorrow,s Health Care Heroes, HARRISBURG, Pa., Nov. ... working to build tomorrow,s health care,workforce by showcasing ... Careers Week., "This special week helps put ... paths that will benefit millions of,Pennsylvanians," said Governor ...
Cached Medicine News:Health News:Can Vitamins and Minerals Prevent Hearing Loss? 2Health News:Can Vitamins and Minerals Prevent Hearing Loss? 3Health News:Can Vitamins and Minerals Prevent Hearing Loss? 4Health News:Scientist Warns Industry Not to Ignore Potential Health Threat to Pharmacy Workers 2Health News:Scientist Warns Industry Not to Ignore Potential Health Threat to Pharmacy Workers 3Health News:Measles Initiative Supports Disease Prevention for Children in China's Earthquake Zone 2Health News:Measles Initiative Supports Disease Prevention for Children in China's Earthquake Zone 3Health News:Historic Lawsuit Challenges Unacceptable Delays in Delivering Benefits to America's Veterans by Department of Veterans Affairs 2Health News:Historic Lawsuit Challenges Unacceptable Delays in Delivering Benefits to America's Veterans by Department of Veterans Affairs 3Health News:Historic Lawsuit Challenges Unacceptable Delays in Delivering Benefits to America's Veterans by Department of Veterans Affairs 4Health News:Governor Rendell Shines Health Careers Week Spotlight on 8 In-Demand Occupations 2Health News:Governor Rendell Shines Health Careers Week Spotlight on 8 In-Demand Occupations 3
... for LASIK surgery and other types ... the corneal interface and/or stromal bed. ... the flap and helps elevate the ... irrigation. 23G x 7/8in (.60 x ...
... designed for LASIK surgery and other ... irrigate the corneal interface and/or stromal ... under the flap and helps elevate ... multi-directional irrigation. 21G x 7/8in (.80 ...
For injecting viscoelastic to all meridians of the anterior chamber and to coat intraocular lenses. 20G x 7.8in (.90 x 22mm)....
Cannula tip is specially rounded, extra smooth for safe insertion through wound and manipulation in the anterior chamber. 23G x 7/8 in (.60 x 22mm). .3mm end port. Olive shape tip is 2mm long x 1mm w...
Medicine Products: