Navigation Links
Clinical Data Suggest Decreased Bleeding Risk in People With Severe,Hemophilia A While Maintaining Factor VIII Levels Above One Percent

Results Highlighted in Oral Presentation at International Symposium of Thrombosis and Haemostasis

GENEVA, July 10, 2007 /PRNewswire-FirstCall/ -- Baxter Healthcare Corporation today announced the presentation of findings from the ADAPT (Analysis of Data from ADVATE(R) Prospective Trials) study program database showing a statistically significant relationship between the duration of time spent with factor VIII blood levels below one international unit per deciliter (1 IU/dL, one percent of normal factor VIII level) and an increase in the annual bleed rate in people with hemophilia A. The findings from ADAPT suggest that maintaining trough levels above 1 IU/dL with prophylactic therapy may decrease the number of bleeding episodes, particularly in children.

"Until now there has been insufficient clinical evidence to demonstrate that factor VIII levels less than 1 IU/dL are associated with increased bleeding in patients receiving prophylaxis for the management of hemophilia A," said Peter W. Collins M.D., FRCP, FRCPath, Department of Haematology, University Hospital of Wales, Cardiff, U.K.

"These results suggest that decreasing the amount of time a patient spends with a factor VIII less than 1 IU/dL will reduce the number of bleeds. This can be achieved in part by improving adherence to prescribed prophylaxis, while measurement of trough factor VIII levels in some patients may help individual tailoring of factor VIII dosing regimens."

Dr. Collins presented data from the ADAPT group showing an analysis of 48 children (one to six years of age) and 100 adolescents and adults (10 to 65 years of age) with severe hemophilia A and factor VIII levels less than 1 IU/dL who participated in ADVATE clinical trials. All participants were initially evaluated in a 48-hour pharmacokinetic study to measure their rate of clearance of ADVATE prior to initiation of prophylactic therapy. The 10 to 65 years old grou
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
6. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
7. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
10. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
11. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
Post Your Comments:
(Date:7/11/2014)... , July 11, 2014 ... Market by Composition of Material, Application (Healthcare, Homeland ... End Product (Personal Instrument, Hand-Held Instruments, Fixed, and ... Analysis to 2013 - 2020", published by MarketsandMarkets, the Scintillator ... of 5.62% from 2014 to 2020, and reach ...
(Date:7/11/2014)... , July 11, 2014  Australian drug delivery company, ... it has raised A$19.3 million via a placement of ... , the U.S., Asia ... from a share purchase plan (SPP) to be offered ... be made in two tranches. "This capital ...
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... the addition of the "Immunoprotein Diagnostic Testing ... at the highest CAGR of 6% and is ... report to their offering. ... for immunoprotein diagnostic testing has been segmented according ...
Breaking Medicine Technology:Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
(Date:7/12/2014)... Restore My Vision Today is a ... a couple boasting very impressive credentials on the field ... Today as a way to help consumers do without ... their respective patients’ treatments . , In ... trove of pertinent information relevant to eye care like:, ...
(Date:7/12/2014)... 2014 The largest pure occupational medicine ... to announce that it will be opening its fifth ... will join four Atlanta-based Nova Medical Centers’ locations. The ... Deans Bridge Road, and will be open from 8:30 ... “With Nova’s treatment philosophy of rapid return-to-work and decreased ...
(Date:7/11/2014)... 2014 Recently, DressyQuinceanera.com, a well-known wedding ... Dama dresses to its online category. Furthermore, the ... at deeply discounted rates, up to 62% off. , ... equally excellent in terms of quality and style. All ... discounts are also offered for the company’s other items: ...
(Date:7/11/2014)... 11, 2014 Ticket Down reports that tickets ... and 3rd place World Cup Match between Brazil and ... will take place on Saturday, July 12th at Estadio Nacional ... Finals will take place on Sunday, July 13th at Estadio ... All tickets for the 2014 World Cup are guaranteed to ...
(Date:7/11/2014)... FRIDAY, July 11, 2014 (HealthDay News) -- Reducing the ... incidence of Lyme disease and other tick-borne infections ... that deer populations can be manipulated to reduce human ... of contracting Lyme disease," the researchers wrote. White-tailed ... which transmit Lyme disease to people. The study ...
Breaking Medicine News(10 mins):Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Nova Medical Centers To Open New Facility in Augusta, Georgia 2Health News:DressyQuinceanera.com: Beautiful Quinceanera Dama Dresses At Low Prices 2Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2
... Survivors , Breast cancer survivors, particularly older ... non-cancer causes than from breast cancer. , ... longer, and many are dying of causes unrelated ... with the National Cancer Institute of Canada Clinical ...
... responsive to treatment than those with HPV-negative tumors , , ... cancer patients whose tumors test positive for human papillomavirus ... treatment than those who test negative, a new study ... to be responsible for most cervical cancers, has recently ...
... Commitment to Healthy Eating, Active Living and Safety ... ... the fourth,quarter of 2007, Kaiser Permanente approved 778 community benefit grants,totaling ... improve the health of the communities that it,serves. Funds were pledged ...
... Memorial,HealthCare, corporate parent of Northwestern Memorial Hospital, appointed,at ... to the Northwestern,Memorial Foundation,s Boards of Directors., ... as president of the Friends of Prentice,board of ... Hospital,s,Campaign Steering Committee. Gordon is chairman of Boyden ...
... and 100 mcg/hr) Not Affected, RARITAN, N.J., ... said today that all lots of 25,microgram/hour (mcg/hr) ... in the United States and all 25 mcg/hr ... States are being voluntarily,recalled as a precaution from ...
... Help Pediatric Group Improve Claims Processing, ... Appointment Scheduling and Patient Statements, ... completed an agreement with Huntsville Pediatric Associates,to provide ... helps improve appointment scheduling, medical,billing, electronic claims submission, ...
Cached Medicine News:Health News:Other highlights in the Feb. 12 JNCI 2Health News:Other highlights in the Feb. 12 JNCI 3Health News:Other highlights in the Feb. 12 JNCI 4Health News:Kaiser Permanente Approves $29 Million in Community Benefit Grants 2Health News:Kaiser Permanente Approves $29 Million in Community Benefit Grants 3Health News:Northwestern Memorial HealthCare and Northwestern Memorial Foundation Elect New Members to Board of Directors 2Health News:PriCara(TM) Recalls 25 mcg/hr DURAGESIC(R) (fentanyl transdermal system) CII Pain Patches 2Health News:Huntsville Pediatric Associates Selects DST Health Solutions' Practice Management Solution for Billing, Accounts Receivable 2
... Bird and Cronin, ... manufacturer of Patient Footwear, ... Patient Care Products. Our ... highest quality and available ...
FREEDOM® Memory Thumb Spica lets you make a custom splint in minutes. Immerese in 160 F water until pliable, and remove. Amazingly, it maintains its shape and is ready to be precisely, profession...
Qualcare™ Thumb Spica...
... of the thumb, known as deQuervain's tenosynovitis, ... ThumSaver CMC Long provides wrist and thumb ... is positioned for pinch without straining to ... a sleeve. Also ideal following cast removal ...
Medicine Products: