Navigation Links
Clinical Data Reported on Vidaza in Hematologic Malignancies and,Advanced Solid Tumors

sor genes, thereby promoting tumor growth. MGCD0103 is an orally-administered, selective HDAC inhibitor, which targets specific class I HDAC isotypes. Preclinical data suggest that these HDAC isotypes are important in cancer biology and, consequently, such selective HDAC inhibitors may have increased efficacy and reduced toxicity compared to non-selective inhibitors.

Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) (Trial 005)

Data presented in a poster session by Guillermo Garcia-Manero, M.D., principal investigator, Associate Professor of Medicine and Chief, Section of Myelodysplastic Syndromes, Department of Leukemia, M.D. Anderson Cancer Centre, demonstrated that combination treatment with MGCD0103 and Vidaza(r) (azacitidine for injection) resulted in a 30 percent response rate for all patients, and a 37 percent response rate in the active dose ranges previously reported. Of the 37 patients in this trial, eleven patients (two MDS patients and nine AML patients) experienced objective clinical responses. In addition, the combination therapy showed good pharmacodynamic properties and acceptable safety in these patients.

"MGCD0103 and Vidaza are two epigenetic agents that have demonstrated single-agent activity in AML and MDS," said Dr. Garcia-Manero. "In this study we found that these agents can be given together, and that the resulting clinical activity is better than expected from each agent alone."

"We are very encouraged by the single-agent activity to date in our Hodgkin's lymphoma trial. These patients have progressive disease after receiving multiple prior therapies and there are currently no approved alternative treatments available to them," said Donald F. Corcoran, President and Chief Executive Officer of MethylGene. "In addition, the responses in our Vidaza-MGCD0103 combination trial are consistent with our earlier data. The data from these two ongoing trials have given us potential direction for registratio
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: MCET.OB ... composition of matter, biological targets, mechanism of action, methods ... This patent application describes a novel class ... which interfere with the basic homeostatic cellular processes in ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness & ... Center by the Medical Fitness Association, a non-profit organization ... their full potential. The Cadence Fitness & Health Center ... suburbs and second in the Chicagoland area. ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
(Date:7/9/2014)... research into the metabolism of stromal support cells and ... of these cell types in the development of diseases ... conditions and cancer. That was the conclusion of a ... in the leading journal Nature . , Prof. ... wake-up call. The metabolism of cancer cells has been ...
(Date:7/9/2014)... found that fecal transplantation is effective and safe for ... is the result of a study led by Colleen ... Gastrointestinal Medicine at The Women,s Medicine Collaborative. The study ... of print in the American Journal of Gastroenterology ... diff , has increased to epidemic proportions over the ...
(Date:7/9/2014)... The Miriam Hospital have found that people with ... depressed have difficulty sticking to a pulmonary rehabilitation ... women, and screening and brief treatment of depression ... study and its findings are published in print ... obstructive pulmonary disease is a common and often ...
(Date:7/9/2014)... news release is available in French . ... factors in 14 year old teens, including brain structure and ... 70% accuracy who will go on to develop binge drinking ... of conscientiousness, and other variables such as life events and ... of binge drinking. Whether or not the child had ...
(Date:7/9/2014)... Researchers from Montefiore Medical Center and ... Yeshiva University will present new findings at the Alzheimer,s ... July 17 in Copenhagen, Denmark. Data from the four ... from cognitive normality to mild cognitive impairment and dementia. ... Study , established in 1980 to examine healthy brain ...
Breaking Medicine News(10 mins):Health News:Wake-up call for more research into cell metabolism 2Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:What drives a child to abuse alcohol? 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3
... antidepressants, effectiveness , , THURSDAY, April 17 (HealthDay News) -- ... brain cells to their more plastic youthful condition in ... provides a possible new explanation for the antidepressant activity ... that it could be used to treat other conditions ...
... Funds Awarded to Reconstruct Devastating,Injuries;, Not all ... April 17 Members of,the American Society of ... the next five years developing groundbreaking therapies to ... Afghanistan. The U.S.,Department of Defense (DoD) has awarded ...
... Known Risks of Lead Paint in,Products Sourced in China, ... WASHINGTON, April 17 Based on a review of ... for 2006,and 2007, major industrial and other sectors affected ... informing shareholders of market risks they,face due to toxic ...
... 17 MSA (NYSE: MSA ), the,global leader ... protect people,s health and safety, announced today that it,will ... via the,Internet on Thursday, May 1, 2008 at 10:00 ... Investors and interested parties will have the opportunity to ...
... other diseases that affect red blood cells , , THURSDAY, April ... skin, says a new study that showed the skin plays ... and in stimulating kidney production of the hormone erythropoietin (EPO) ... blood cells that carry and deliver oxygen throughout the body. ...
... Nearly 20 percent of military service members who have ... -- report symptoms of post traumatic stress disorder or ... sought treatment, according to a new RAND Corporation study. ... returning service members report that they experienced a possible ...
Cached Medicine News:Health News:Prozac Makes Old Brain Cells Young 2Health News:Prozac Makes Old Brain Cells Young 3Health News:Plastic Surgeons Play Pivotal Role in War Injury Research 2Health News:Plastic Surgeons Play Pivotal Role in War Injury Research 3Health News:'Toxic Stock Syndrome' Report: Many Companies Are Keeping Shareholders in the Dark on Potential Recalls, Bans, and Other Risks 2Health News:'Toxic Stock Syndrome' Report: Many Companies Are Keeping Shareholders in the Dark on Potential Recalls, Bans, and Other Risks 3Health News:'Toxic Stock Syndrome' Report: Many Companies Are Keeping Shareholders in the Dark on Potential Recalls, Bans, and Other Risks 4Health News:'Toxic Stock Syndrome' Report: Many Companies Are Keeping Shareholders in the Dark on Potential Recalls, Bans, and Other Risks 5Health News:MSA Schedules First Quarter Earnings Webcast 2Health News:Mice Can Sense Oxygen Through Their Skin 2Health News:Study finds 1 in 5 Iraq and Afghanistan veterans suffer from PTSD or major depression 2Health News:Study finds 1 in 5 Iraq and Afghanistan veterans suffer from PTSD or major depression 3Health News:Study finds 1 in 5 Iraq and Afghanistan veterans suffer from PTSD or major depression 4Health News:Study finds 1 in 5 Iraq and Afghanistan veterans suffer from PTSD or major depression 5
... tilt, user programmable memory two position ... on both chair sides, solid cast ... Single button folding armrests and headrest, ... on both chair sides, ergonomically contoured ...
... chair for examination of the ... adjustable from 540 mm to ... an independent foot switch. The ... and incorporates a multi-adjustable headrest, ...
Heine Beta 200 Streak Retinoscope 3.5v w/Twist Lock for Welch-Allyn style handles....
Heine Beta 200 Streak Retinoscope 3.5v...
Medicine Products: