Navigation Links
Clinical Data Reported on Vidaza in Hematologic Malignancies and,Advanced Solid Tumors

sor genes, thereby promoting tumor growth. MGCD0103 is an orally-administered, selective HDAC inhibitor, which targets specific class I HDAC isotypes. Preclinical data suggest that these HDAC isotypes are important in cancer biology and, consequently, such selective HDAC inhibitors may have increased efficacy and reduced toxicity compared to non-selective inhibitors.

Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) (Trial 005)

Data presented in a poster session by Guillermo Garcia-Manero, M.D., principal investigator, Associate Professor of Medicine and Chief, Section of Myelodysplastic Syndromes, Department of Leukemia, M.D. Anderson Cancer Centre, demonstrated that combination treatment with MGCD0103 and Vidaza(r) (azacitidine for injection) resulted in a 30 percent response rate for all patients, and a 37 percent response rate in the active dose ranges previously reported. Of the 37 patients in this trial, eleven patients (two MDS patients and nine AML patients) experienced objective clinical responses. In addition, the combination therapy showed good pharmacodynamic properties and acceptable safety in these patients.

"MGCD0103 and Vidaza are two epigenetic agents that have demonstrated single-agent activity in AML and MDS," said Dr. Garcia-Manero. "In this study we found that these agents can be given together, and that the resulting clinical activity is better than expected from each agent alone."

"We are very encouraged by the single-agent activity to date in our Hodgkin's lymphoma trial. These patients have progressive disease after receiving multiple prior therapies and there are currently no approved alternative treatments available to them," said Donald F. Corcoran, President and Chief Executive Officer of MethylGene. "In addition, the responses in our Vidaza-MGCD0103 combination trial are consistent with our earlier data. The data from these two ongoing trials have given us potential direction for registratio
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
(Date:8/31/2015)... -- Thousands of people will peacefully demonstrate their frustration ... epidemic at dozens of rallies across the country today. ... the United States has experienced skyrocketing rates ... heroin, yet the President has never once spoken publicly ... to President Obama , rally organizers compared his failure ...
(Date:8/31/2015)... 2015 With increasing clinical applications, the ... rise in active partnerships. The primary reason for ... quantitate CD4 cell markers in human immunodeficiency virus ... New analysis from Frost ... Market ( http://www.frost.com/nf0e ), finds the market earned ...
(Date:8/31/2015)... Aug. 31, 2015 The Wolf Administration today ... Pennsylvania State Police and local ... naloxone. Heroin and opioid overdose are the ... , killing more individuals than those involved in ... died from a drug overdose. " ...
Breaking Medicine Technology:Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 3Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 4Departments of Drug & Alcohol Programs and Health Announce Report 289 Pennsylvanian Lives Saved by Naloxone 2Departments of Drug & Alcohol Programs and Health Announce Report 289 Pennsylvanian Lives Saved by Naloxone 3
(Date:8/31/2015)... ... August 31, 2015 , ... ... include a wealth of information for specific translation services within the medical and ... an incredible track record of successful work. , ITC Global Translations specializes in ...
(Date:8/31/2015)... ... , ... Southern Vacation Rentals – a member of the locally owned and ... property management company, 360 Blue, in support of the Sonder Project, a global ... two companies will collect any unopened food items left in vacation rentals after guest ...
(Date:8/31/2015)... Los Angeles, CA (PRWEB) , ... August 31, 2015 , ... ... August 16 by CDA Press, the expert guest author addressed the topic of treating ... The author explained that, while steroids were shown to slightly improve physical function in ...
(Date:8/31/2015)... ... August 31, 2015 , ... Wound Care ... the company’s second Introduction to Hyperbaric Medicine Course. The next UHMS approved 40-hour ... Queen Mary Hotel in Long Beach, CA. The meeting is open for registration ...
(Date:8/31/2015)... ... August 31, 2015 , ... Women’s Excellence in ... unique to the Lake Orion area. This program is one of the most ... weight management program will incorporate group fitness and nutritional consultations to help people ...
Breaking Medicine News(10 mins):Health News:GoMarketing Announces Major Updates to ITC Global Translations Website http://www.ITCGlobalTranslations.com 2Health News:GoMarketing Announces Major Updates to ITC Global Translations Website http://www.ITCGlobalTranslations.com 3Health News:Southern Vacation Rentals Partners with the Sonder Project 2Health News:Southern Vacation Rentals Partners with the Sonder Project 3Health News:Article on Steroid Use for Back Pain Highlights the Effectiveness of Surgery in Treating Disk Pain, says Dr. Seyed M. Rezaian 2Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 2Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 3Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 4
... Reinberg HealthDay Reporter , THURSDAY, Jan. 19 (HealthDay News) ... in the past year, a new government report shows. ... mental illness, twice as many as those aged 50 and older ... a mental illness in the last year (23 percent vs. nearly ...
... Approximately 3 percent of the U.S. population suffers ... quality of life. The condition, known as Generalized Anxiety ... a host of physical symptoms, including fatigue, muscle tension, ... Georgia study shows that regular exercise can significantly reduce ...
... four times more likely to develop liver cancer compared to ... estrogen. Although this gender difference has been known for a ... and androgens promote -- liver cancer remain unclear., Now, new ... lab of Klaus Kaestner, PhD, professor of Genetics in the ...
... By Serena Gordon HealthDay Reporter , WEDNESDAY, Jan. 18 ... a normal result on a bone density scan -- a test ... able to wait as long as 15 years before getting another ... generally need follow-up scans much sooner than that, the study authors ...
... body,s most complex organs soon may become easier because ... Howard Matthew and Yinlun Huang, professors of ... grant from the National Science Foundation (NSF) to develop ... used to analyze and more effectively predict responses to ...
... ,Aromatase inhibitors (AIs) prevent the conversion of androgens to estrogens, ... cancer. This study of 36 pre-menopausal women consisted of ... between red wine and white wine in their effects on ... followed by white wine (or vice versa), each beverage for ...
Cached Medicine News:Health News:1 in 5 U.S. Adults Suffers Mental Ills: Report 2Health News:1 in 5 U.S. Adults Suffers Mental Ills: Report 3Health News:UGA College of Education finds exercise reduces anxiety symptoms in women 2Health News:Gender differences in liver cancer risk explained by small changes in genome 2Health News:Some Women Can Go Longer Between Bone Checks: Study 2Health News:Some Women Can Go Longer Between Bone Checks: Study 3Health News:NSF grant will aid Wayne State professors' mathematical modeling of fatty liver predictors 2
... a high performance temperature controlled shaker which ... speed and incubation time are fully programmable ... are displayed on the LCD in real ... the microplates provide uniform incubation with less ...
... The iEMS Incubator/Shaker HT ... Thus, the iEMS Incubator/Shaker HT ... as DNA hybridization and primer ... is available as a one-cabinet ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
Form: Cream-colored powder Moisture: 10% Ash: 6.5% Gel Strength (1.5%): 550 950 gm/cm 2 Gel pH (1.5%): 6.0 7.5 Gel Point (1.5%): 34 38C Melting Point (1.5%): 84 88C Application: Bacterial ...
Medicine Products: