Navigation Links
Clinical Data Reported on Vidaza in Hematologic Malignancies and,Advanced Solid Tumors

S and AML Patients

CHICAGO, Ill. June 2, 2007 - Pharmion Corporation (NASDAQ:PHRM) and MethylGene Inc. (TSX:MYG) today announced preliminary Phase II and Phase I/II data for their lead oncology product candidate, MGCD0103, a novel, isotype-selective histone deacetylase (HDAC) inhibitor which showed significant anti-tumor activity in patients with Hodgkin's lymphoma, Myelodysplastic Syndromes and acute myelogenous leukemia. The data were presented Saturday at the 43rd American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Hodgkin's Lymphoma (Trial 010)

Data presented show an objective complete and partial response rate of 40 percent and a disease control rate of 45 percent in a population of patients that had relapsed disease or were refractory (unresponsive) to all previous treatments, including, in many cases, bone marrow transplantation. Overall, 75 percent of patients experienced a reduction in tumor size, with 60 percent experiencing a tumor reduction of greater than 30 percent.

"It is striking that single-agent therapy with MGCD0103 achieved such impressive objective clinical responses in this population," said Anas Younes, M.D., principal investigator and Professor of Medicine and Director, Clinical Investigation and Translational Research in the Department of Lymphoma/Myeloma, M.D. Anderson Cancer Center. "No approved therapies exist for patients suffering from Hodgkin's lymphoma that has progressed following transplantation. With a novel mechanism of action and an oral route of administration, MGCD0103 would be a welcome and desirable addition to the Hodgkin's lymphoma armamentarium."

The data were presented as part of a clinical symposium titled, "Breaking the Silence of the Genome: HDAC Inhibitors," which focused on the progress and potential of this emerging therapeutic category. The HDACs are enzymes that mediate histone deacetylation, an epigenetic form of gene regulation that may silence tumor suppres
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
(Date:12/16/2009)... WALTHAM, Mass., Dec. 16 According to ... medical technology market intelligence, health care reforms in ... stent market in 2009, and will continue to ... new Asia Pacific Markets for Interventional Cardiology ... by the Chinese government will allow the Chinese ...
(Date:12/16/2009)... Ga., Dec. 16 Greenway Medical Technologies, ... electronic health record (EHR), practice management and interoperability ... in KLAS" awards in the annual 2009 ... & Professional Services report. ,, For practices ... Chart was named Best in KLAS in ...
(Date:12/16/2009)... 16 /PRNewswire/ -- Sanofi Pasteur, ... announced today that it has entered into ... to develop and commercialize its prophylactic vaccine ... Staphylococcus aureus or MRSA. MRSA are ... sometimes referred to as multidrug-resistant Staphylococcus ...
Breaking Medicine Technology:Major Health Care Reforms in China Supported Growth of More Than 20% in the Drug-Eluting Stent Market in 2009, According to Millennium Research Group 2Major Health Care Reforms in China Supported Growth of More Than 20% in the Drug-Eluting Stent Market in 2009, According to Millennium Research Group 3Greenway Medical Technologies' PrimeSuite Wins Three Best in KLAS Awards 2Greenway Medical Technologies' PrimeSuite Wins Three Best in KLAS Awards 3Greenway Medical Technologies' PrimeSuite Wins Three Best in KLAS Awards 4Sanofi Pasteur Obtains License from Syntiron to Develop & Commercialize Vaccine to Prevent Staphylococcus Infections 2Sanofi Pasteur Obtains License from Syntiron to Develop & Commercialize Vaccine to Prevent Staphylococcus Infections 3Sanofi Pasteur Obtains License from Syntiron to Develop & Commercialize Vaccine to Prevent Staphylococcus Infections 4Celebrity Dancer Karina Smirnoff Speaks Out for the First Time on How ADHD Has Impacted Her Life 57322 1Celebrity Dancer Karina Smirnoff Speaks Out for the First Time on How ADHD Has Impacted Her Life 57322 2Celebrity Dancer Karina Smirnoff Speaks Out for the First Time on How ADHD Has Impacted Her Life 57322 3Celebrity Dancer Karina Smirnoff Speaks Out for the First Time on How ADHD Has Impacted Her Life 57322 4Celebrity Dancer Karina Smirnoff Speaks Out for the First Time on How ADHD Has Impacted Her Life 57322 5Celebrity Dancer Karina Smirnoff Speaks Out for the First Time on How ADHD Has Impacted Her Life 57322 6Celebrity Dancer Karina Smirnoff Speaks Out for the First Time on How ADHD Has Impacted Her Life 57322 7Affinion Security Center Launches Benefits to Help Detect and Resolve Medical Identity Theft 57320 1Affinion Security Center Launches Benefits to Help Detect and Resolve Medical Identity Theft 57320 2Affinion Security Center Launches Benefits to Help Detect and Resolve Medical Identity Theft 57320 3Poniard Pharmaceuticals to Present at the 2009 UBS Global Life Sciences Conference 14084 1Poniard Pharmaceuticals to Present at the 2009 UBS Global Life Sciences Conference 14084 2
(Date:12/17/2009)... employee engagement levels trended in 2009 and over the past three ... ... Charlotte, N.C. (Vocus) December 17, 2009 -- Morehead, the human capital ... Engagement: A Year in Review.” The free hour-long webinar will ... , , ,Join Rod Wilkes, M.S., Morehead’s SVP, Consulting Services ...
(Date:12/17/2009)... Stress Reduction Therapy or NSRTSM is found very effective in ... as allergies, asthma, migraines, chronic fatigue and a wide array ... country are using this holistic therapy including over 50 branded ... ... Allentown, PA (Vocus) December 16, 2009 -- BioVeda Health ...
(Date:12/17/2009)... marketing techniques, life coaching company puts free i-phone & ... http://itunes.apple.com/us/app/attainment-life-management/id345691804?mt=8 . For the Free download. , ... ... -- Utah based Attainment Life Management & Coaching is ... everything in life simplified into one little hand held ...
(Date:12/16/2009)... Health care sector revenue increased by 5.7 percent ... trillion in 2007, according to new data from ... under the North American Industry Classification System as ... These figures come from the 2008 Service ... a series of tables which provides estimates of ...
(Date:12/16/2009)... Annual Gala Raises Significant Funds to Benefit of Children ... Christine Taylor, Gary Cole and Zachary Levi Join ... ,, LOS ANGELES, Dec. 16 At its ... three remarkable individuals. Hasbro President & CEO ... Award in recognition of his far-reaching philanthropic leadership ...
Breaking Medicine News(10 mins):Health News:Morehead Presents Webinar on "The State of Employee Engagement: A Year in Review" 2Health News:BioVeda Health and Wellness Center of Allentown, PA Announces Its Grand Opening 2Health News:BioVeda Health and Wellness Center of Allentown, PA Announces Its Grand Opening 3Health News:BioVeda Health and Wellness Center of Allentown, PA Announces Its Grand Opening 4Health News:BioVeda Health and Wellness Center of Allentown, PA Announces Its Grand Opening 5Health News:Attainment Life Management & Coaching has just Debuted its Free Application for I-Phone and I-Touch Users 2Health News:Census Bureau: Health Care Industries Showed Modest Growth in Revenue in 2008 2Health News:Census Bureau: Health Care Industries Showed Modest Growth in Revenue in 2008 3Health News:The Help Group Honors Brian Goldner, Mary Urquhart and Max Mayer at its Teddy Bear Ball Featuring Ben Stiller and Celebrity Guests 2Health News:The Help Group Honors Brian Goldner, Mary Urquhart and Max Mayer at its Teddy Bear Ball Featuring Ben Stiller and Celebrity Guests 3Health News:The Help Group Honors Brian Goldner, Mary Urquhart and Max Mayer at its Teddy Bear Ball Featuring Ben Stiller and Celebrity Guests 4Health News:The Help Group Honors Brian Goldner, Mary Urquhart and Max Mayer at its Teddy Bear Ball Featuring Ben Stiller and Celebrity Guests 5
... A universal vaccine effective against several ... of testing, according to Dr. Christine Turley of the ... director of clinical trials and clinical research at the ... study,s principal investigator, said that VaxInnate,s M2e universal vaccine ...
... religious fear of vaccination leading to increase, CDC report ... parents, refusal to vaccinate children seems to be behind ... federal officials said Thursday. , Between Jan. 1 and ... been reported in the United States, many of them ...
... NEWTON, Mass., Aug. 20 Questex Media ... and owner of,American Spa and American Salon ... Shows, the International Esthetics, Cosmetics & Spa,Conferences ... announced the,acquisition of SpaTrade, which produces industry ...
... fastest growing ... 500 list, BETHESDA, Md., Aug. 20 Integrity Capital ... it has,been ranked the 2nd fastest growing insurance related company ... 156 on the 2008 Inc. 500 list of,fastest growing companies ...
... Mich., Aug. 20 WXYZ- TV/Channel 7 and The,Detroit ... of,Detroit metro area children a "boost" at the 31st ... will be held Sunday, August 24,2008 from 10 a.m. ... of African,American History. Since its inception in 1977, "Healthy ...
... Aug. 20 Fourteen physicians who have been,part of ... enhance,the care and service they provide to their patients ... care physicians, and we are delighted they,have decided to ... chief executive officer. "We look forward to working with,them ...
Other Medicine News:Health News:Measles Cases Highest Since 1996 2Health News:Measles Cases Highest Since 1996 3Health News:Questex Acquires Leading Spa Industry Portal and Spa Executive Business Networking Site and Events 2Health News:Questex Acquires Leading Spa Industry Portal and Spa Executive Business Networking Site and Events 3Health News:Integrity Capital Partners Ranked 2nd Fastest Growing Insurance Related Company in US by Inc. Magazine 2Health News:WXYZ-TV/Channel 7 is 'On Your Side' With Healthy Living For Kids; Free Immunizations for Children on Sunday, August 24 at Charles H. Wright Museum of African American History 2Health News:WXYZ-TV/Channel 7 is 'On Your Side' With Healthy Living For Kids; Free Immunizations for Children on Sunday, August 24 at Charles H. Wright Museum of African American History 3Health News:Commonwealth Medical Group Physicians to Join Aurora Health Care 2
... to optimize the accuracy and precision of ... is widely recognized by customers throughout the ... over the years and now covers a ... including filter tips, certified pure tips, stepper ...
... Long Reach Pipet Tips (P2 - P10) - ... DNA and protein binding. Non-reactive. Beveled and referenced. ... to 10 L. Produced & packaged completely by ... Sterile Racked packaged 96 tips/rack and 10 racks/cs. ...
... Binding, Graduated, Pipet Tips (P2 - P10) - ... DNA and protein binding. Non-reactive. Beveled and referenced. ... to 10 L. Produced & packaged completely by ... Sterile Racked packaged 96 tips/rack and 10 racks/cs. ...
... Packed conveniently in plastic-wrapped racks of 96 ... useno need to autoclave. Sterilized Diamond Tips ... sterilization and are delivered with a certificate ... Sterilized Diamond Tips are certified free of ...
Medicine Products: