Navigation Links
Clinical Data Reported on Vidaza in Hematologic Malignancies and,Advanced Solid Tumors

cer cells that are no longer responsive to normal growth control mechanisms. Non-proliferating cells are relatively insensitive to Vidaza.

About Epigenetics

Azacitidine is the first of a new class of anti-cancer compounds called epigenetic therapies. DNA methylation and histone deacetylation are two of the more studied epigenetic regulators of gene expression. Epigenetics refers to changes in the regulation of gene expression. Epigenetic changes can silence gene expression and, unlike DNA mutations, may be reversed by targeting the enzymes involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation has been demonstrated in vitro and in vivo in hematological malignancies and in solid tumors. These key growth control genes can be re-expressed in cancer cells when DNA hypermethylation is reversed by Vidaza and/or inappropriate histone deacetylation is inhibited by MGCD0103. The epigenetic approach to cancer therapy is that rather than using molecules that kill both normal and tumor cells, the silenced genes are reactivated through targeted epigenetic therapy, re-establishing the cancer cell's natural mechanisms to control abnormal growth.

Important Safety Information

Vidaza is contraindicated in patients with a known hypersensitivity to azacitidine or mannitol and in patients with advanced malignant hepatic tumors.

In clinical studies, the most commonly occurring adverse reactions by SC route were nausea (70.5%), anemia (69.5%), thrombocytopenia (65.5%), vomiting (54.1%), pyrexia (51.8%), leukopenia (48.2%), diarrhea (36.4%), fatigue (35.9%), injection site erythema (35.0%), constipation (33.6%), neutropenia (32.3%) and ecchymosis (30.5%). Other adverse reactions included dizziness (18.6%), chest pain (16.4%), febrile neutropenia (16.4%), myalgia (15.9%), injection site reaction (13.6%), aggravated fatigue (12.7%) and malaise (10.9%). The most common adverse
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
(Date:7/23/2014)...  The management team at Columbia Laboratories, Inc. ... conference call on July 31, 2014, to discuss ... 30, 2014.  The call details are as follows:Date: ... EDTDial-in numbers: , Toll free: (877) 870-4263 (U.S.), ... archive): , www.columbialabs.com , under ,Investor, or ...
(Date:7/23/2014)... ORANGE, Calif. , July 23, 2014 ... will gather in Las Vegas ... event. Spearheaded by educator, author, forward thinker and private ... to bring experts together to candidly discuss clinical and ... two day event is a unique opportunity to welcome ...
(Date:7/23/2014)... , July 23, 2014  Silk Road ... the transcarotid treatment of intra- and extra-cranial cerebrovascular ... P. Wallace to the position of Chief ... lead the company,s Research and Development efforts across ... Prior to joining Silk Road ...
Breaking Medicine Technology:Columbia Laboratories to Discuss Second Quarter 2014 Financial Results on July 31st Conference Call 22014 DOCtalk Registration Now Open 22014 DOCtalk Registration Now Open 3Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 2Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 3
... Analyzes the Effectiveness and Safety of Statin Use for Those Who Need It , ... Recommendations for Choosing a ,Best Buy, Statin and Strategies for ... YONKERS, N.Y. , June 29 ... ) caution that the benefits of statin use by children and some women may ...
... Initiative Launched on Biosafety , , ... WASHINGTON , June 29 Remember chemistry sets, ham radio, amateur ... 2,000 people from around the world belong to the Do-It-Yourself Biology (DIYbio) community, ... bio-monitoring, to new treatments for diseases. , ...
Cached Medicine Technology:Consumer Reports Health Questions Use of Statins By Children and Some Women 2Consumer Reports Health Questions Use of Statins By Children and Some Women 3Consumer Reports Health Questions Use of Statins By Children and Some Women 4Consumer Reports Health Questions Use of Statins By Children and Some Women 5Consumer Reports Health Questions Use of Statins By Children and Some Women 6Consumer Reports Health Questions Use of Statins By Children and Some Women 7Responsible Science for Do-It-Yourself Biologists 2
(Date:7/23/2014)... July 24, 2014) If past experience is anything ... are about to get a lot more recognition for ... on the books allowing NPs to provide primary care ... care and better relationships with physicians and administrators, compared ... from Columbia University School of Nursing, published in ...
(Date:7/23/2014)... 2014 Celebrating a decade of philanthropy ... announced the awarding of $1,070,000 in grants to 20 ... recognition of the Foundation’s 1,000th grant. , “The Horizon ... tradition of supporting community-based organizations that are working to ... in the Garden State,” said Robert A. Marino, Horizon ...
(Date:7/23/2014)... body of research suggesting a safe and effective ... breast cancer, with fewer detrimental side effects and ... The study will be published in final format ... and Endocrinology . , Breast cancer is the ... United States. Approximately 70% of breast cancers are ...
(Date:7/23/2014)... 23, 2014 Global Cardio Care, Inc., ... External Counterpulsation (EECP), is celebrating the 100th birthday ... at the health center. , Weber has been ... receiving ongoing EECP therapy since 1999, he no longer ... CEO of Global Cardio Care, introduced the Sara ...
(Date:7/23/2014)... The voice on the recording was low and calm as ... was infected with the human immunodeficiency virus (HIV) that causes AIDS: ... you know I was on the floor flat on my face ... when the recording ended less than 10 minutes later. “Don’t feel ... because it is just God setting you up for something greater,” ...
Breaking Medicine News(10 mins):Health News:New York law offers nurses more recognition, responsibility 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 4Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 5Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:Global Cardio Care Celebrates EECP Patient’s 100th Birthday 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 3
... cancer center at NYU Langone Medical Center, identified for ... (miRNAs) play in melanoma metastasis to simultaneously cause cancer ... to fight abnormal cells. The new study is published ... Cancer Cell. Researchers performed a miRNA ...
... , MONDAY, July 11 (HealthDay News) -- Too much salt ... risk for cardiovascular disease and death, a new study shows. ... pressure and high levels of salt consumption and low levels ... called sodium -- and low potassium appears to convey a ...
... Dotinga HealthDay Reporter , MONDAY, July 11 ... in their homes face a higher risk of developing ... new study finds. The research doesn,t definitively ... it doesn,t say how much smoke is too much. ...
... By Denise Mann HealthDay Reporter , MONDAY, ... reduce the risk of lasting neurological damage, but this lifesaving ... local hospitals don,t have the proper systems in place, and ... arrest to be effective, according to the report in the ...
... DETROIT Na Zhu, a Wayne State University College ... Association Student Research Grant Program award. The program financially ... a cure for tinnitus. Zhu, a Ph.D. ... Professor in the Department of Mechanical Engineering, is developing ...
... that can accumulate to high levels in our body ... linked to an increased risk of cancer and/or impaired ... by Sridhar Mani, at Albert Einstein College of Medicine, ... between environmental exposure to these foreign chemicals (xenogens) and ...
Cached Medicine News:Health News:Researchers identify key role of microRNAs in melanoma metastasis 2Health News:Study: Potassium Boosts Heart Health, Salt Harms It 2Health News:Study: Potassium Boosts Heart Health, Salt Harms It 3Health News:ADHD, Learning Issues May Be Linked to Secondhand Smoke 2Health News:Coordinated Cooling Effort After Cardiac Arrest Can Improve Outcomes 2Health News:Coordinated Cooling Effort After Cardiac Arrest Can Improve Outcomes 3
... The Self-Cath family of ... patients a variety of ... Each catheter is ... grade PVC and has ...
... The Self-Cath family of ... patients a variety of ... Each catheter is ... grade PVC and has ...
IMMCO ANA Elisa meets the guidelines for the laboratory diagnosis and monitoring of systemic autoimmune rheumatic diseases intended for the use of clinical pathologists and laboratory physicians....
... is engineered to distribute contact pressure evenly over ... back, to maximize stability and patient comfort. ... readily conformable to patient anatomy, to provide a ... wool liner is standard on both units, as ...
Medicine Products: