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Clinical Data Reported on Vidaza in Hematologic Malignancies and,Advanced Solid Tumors

h Pharmaceuticals and Sankyo. For more information, please visit the company's web site at www.exelixis.com.

This press release contains forward-looking statements, including without limitation statements related to the safety and potential efficacy of XL999 Words such as "believes," "may," "expects," "plan," "will" and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Exelixis' current expectations. Forward-looking statements involve risks and uncertainties. Exelixis' actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks related to the lengthy, costly and uncertain process of clinical testing of XL999 and the potential failure to demonstrate safety and efficacy and the therapeutic potential of XL999. These and other risk factors are discussed under "Risk Factors" and elsewhere in Exelixis' quarterly report on Form 10-Q for the fiscal quarter ended March 30, 2007 and other filings with the Securities and Exchange Commission. Exelixis expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward- looking statements contained herein to reflect any change in the company's expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.

SOURCE Exelixis, Inc.

Investor Contact: Charles Butler, Director, Corporate Communications,

+1-650-837-7277, cbutler@exelixis.com, or Media Contact: Hal Mackins,

+Corporate

Communications, +1-650-837-7012, hmackins@exelixis.com, both of Exelixis, Inc.






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