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Clinical Data Reported on Vidaza in Hematologic Malignancies and,Advanced Solid Tumors

quarterly report on Form 10-Q for the fiscal quarter ended March 30, 2007 and other filings with the Securities and Exchange Commission. Exelixis expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in the company's expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.

SOURCE Exelixis, Inc.

Investor Contact: Charles Butler, Director, Corporate Communications,

+1-650-837-7277, cbutler@exelixis.com, or

Media Contact: Hal Mackins, Corporate Communications,

+1-650-837-7012, hmackins@exelixis.com, both of Exelixis, Inc.

Web site: http://www.exelixis.com <http://www.exelixis.com/>

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Exelixis Reports Integrated Data From Phase II Clinical Trials of XL999 at ASCO

CHICAGO, June 3, 2007 /PRNewswire-FirstCall via COMTEX News Network/ -- Exelixis, Inc. (Nasdaq: EXEL) reported integrated data from six Phase II clinical trials of XL999 in patients with non-small cell lung cancer (NSCLC), renal cell carcinoma, metastatic colorectal cancer, recurrent ovarian cancer, acute myelogenous leukemia (AML), and multiple myeloma. Results show preliminary anti-tumor activity in patients with NSCLC and AML, as well as a cardiovascular adverse event profile consistent with previously reported data. The data were presented in a poster session on Sunday, June 3, 2007 (Abstract #3591) at the 43rd Annual Meeting of the American Society of Clinical Oncology (ASCO).

The primary objectives of each trial were to determine the response rate and to further evaluate the safety and tolerabilit
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