Navigation Links
Clinical Data Reported on Vidaza in Hematologic Malignancies and,Advanced Solid Tumors

nal trials and/or larger randomized trials which we expect to commence planning for soon."

"These two studies, which represent surprising single agent activity, as well as a very encouraging combination effect with Vidaza, increase our enthusiasm for epigenetic intervention in cancer and the potential for MGCD0103," said Patrick J. Mahaffy, President and Chief Executive Officer of Pharmion Corporation.

Clinical Trial Details

"A Phase II Study of MGCD0103, a Novel Oral Isotype-Selective Histone Deacetylase (HDAC) Inhibitor in Patients with Relapsed or Refractory Hodgkin Lymphoma" (Abstract #8000, Trial 010). Oral, monotherapy treatment with MGCD0103 demonstrated substantial anti-tumor activity in patients with relapsed or refractory Hodgkin's lymphoma. In this study, patients were given MGCD0103 as a single-agent three times per week for four weeks (one cycle) at a starting dose of 110mg. The objectives of this study are to determine the response and disease control rates, as well as safety, toxicity and pharmacodynamic markers. As of May 2007, 22 patients were enrolled and, of these, 20 were evaluable for response analysis.

All patients enrolled in this study had prior chemotherapy ranging from two to nine prior therapies with the median being four. In addition, 59 percent of enrolled patients had prior radiation treatment and 86 percent had prior autologous bone marrow transplant. Overall, eight patients showed objective responses (two complete responses and six partial responses) and nine experienced stable disease (one patient beyond six months) resulting in a response rate of 40 percent and a disease control rate (CR+PR+SD™ 6 months) of 45 percent in this highly-refractory or relapsed population. In total, 75 percent of patients experienced reduction in tumor size; 60 percent experienced tumor reduction greater than 30 percent. Fifty percent of patients remained on treatment for four or more cycles.

Fatigue and gastrointe
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
(Date:8/28/2015)... August 28, 2015 The global ... USD 49.12 billion by 2020, growing at a CAGR ... new report by Grand View Research, Inc. Monitoring services ... 49.7% from 2014 to 2020.      (Logo: ... along with rising incidences of chronic diseases such as ...
(Date:8/27/2015)... 27, 2015 ieCrowd™ today announced the ... development of the company,s supplemental oxygen delivery device, ... being developed by ieCrowd,s subsidiary Smart Oxygen Solutions ... demand for oxygen based on level of activity.  ... for the Smart Oxygen device would require a ...
(Date:8/27/2015)... , Aug. 27, 2015   Proxsys ... Provider (IOPP™) is expanding its population health ... medication-focused transition of care program for hospitals ... Management," provides hospitals with technology systems and ... measures that have been mandated by Center ...
Breaking Medicine Technology:mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2
... Lilly and Company (NYSE: LLY ) has ... for Working Mothers by Working Mother magazine ... http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO) (Logo: http://photos.prnewswire.com/prnh/20031219/LLYLOGO) Celebrating its ... 100 Best Companies initiative selects the nation,s top companies ...
... Wolters Kluwer Health , a leading provider of information ... medicine, nursing, allied health and pharmacy, has announced an ... (JBI), a recognized global leader in evidence-based healthcare resources ... of an expansion of the nursing, allied health, and ...
Cached Medicine Technology:Lilly Celebrates 16th Consecutive Year as One of 100 Best Companies for Working Mothers 2Wolters Kluwer Health and the Joanna Briggs Institute Enter Exclusive Relationship to Deliver Evidence-Based Clinical Resources 2Wolters Kluwer Health and the Joanna Briggs Institute Enter Exclusive Relationship to Deliver Evidence-Based Clinical Resources 3Wolters Kluwer Health and the Joanna Briggs Institute Enter Exclusive Relationship to Deliver Evidence-Based Clinical Resources 4
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... On October 3, 2015, BethAnn Telford of ... North Rim of the Grand Canyon with a shared mission: to beat brain cancer. ... canyon floor, across the canyon, then up to the South Rim over 21.1 miles and ...
(Date:8/27/2015)... ... August 27, 2015 , ... Keck Graduate Institute (KGI), ... received their White Coats at a formal ceremony recognizing them as members of the ... profession on Saturday, August 22. Symbolizing dedication to clinical service and patient care, the ...
(Date:8/27/2015)... ... August 27, 2015 , ... Workflow in labs has ... (qPCR) in the last decade. New features such as multiplexing, microfluidics, and ... flipside, where do lab managers, technicians, and researchers find handy metrics to compare ...
(Date:8/27/2015)... ... August 27, 2015 , ... Allegheny ... of just 20 adult-only medical centers in the United States to receive international ... and lungs. The Extracorporeal Life Support Organization (ELSO) , an international consortium ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... The Naderi ... now be offering Kybella, a cutting-edge, noninvasive procedure to improve submental fat. The ... Kybella provides permanent results without surgery. Dr. Kulak is the only Board Certified ...
Breaking Medicine News(10 mins):Health News:Women Athletes Cross the Grand Canyon to Raise Funds for Brain Cancer Research – October 3rd 2Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 2Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 3Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 4Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 2Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 3Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 2Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 3Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 4Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 3
... holds press conferenceEPHRATA, Pa., April 29 Did ... diagnosed with breast cancer in Pennsylvania who are uninsured or ... - are not aware of the program or how it ... Breast Cancer Coalition (PBCC), in partnership with Senator Vince Hughes, ...
... Up Its ActNEW YORK, April 29 Today, Senator ... by introducing the Safe Baby Products Act, which directs ... contaminants in personal care products marketed to or used ... study by the Campaign for Safe Cosmetics, which revealed ...
... as the lead organizational and strategic planning consultant. Led by General ... of the new healthcare delivery organization. , ... (PRWEB) April 29, 2009 ... care hospital. The hospital will be part of a health village ...
... -- Aesthetic Medical Educators Training (AMET) ... on Aesthetic Procedures over the past five years. ... physicians, nurses, physician assistants and dentists, all of ... practice.These medical professionals have been trained on a ...
... CITY, April 29 Grupo Aeroportuario del Sureste, S.A.B. ... the first privatized airport group in Mexico and operator ... Mexico, announced today that on April 26, 2009 the Mexican ... ("Swine Flu") in Mexico. On April 28, 2009 the World ...
... Controls Limit Vaccine SuppliesDALLAS, April 29 Fears of ... new vaccines, as well as meeting public demand for ... National Center for Policy Analysis. "We are facing ... six vaccines for common childhood illnesses," said NCPA Senior ...
Cached Medicine News:Health News:Free Treatment for Breast Cancer Available in Pennsylvania 2Health News:New Federal Legislation Targets Toxic Chemicals in Baby Bath Products 2Health News:Aesthetic Medical Educators Training Successfully Trains Over 2,000 Medical Professionals on Aesthetic Procedures 2Health News:Swine Flu Outbreak Illustrates Problems in Vaccine Development 2
... Top Rotation provides uncommon bi-directional flexibility, ... Hercules 6700B eliminates any conflicts between ... while providing ample leg room for ... procedures. Removable back and leg sections ...
... The schaerer axis 800 ... specially designed for those ... C-arm access. The stability, ... and the offset positioned ...
... operating table for any application. The ... unlimited C-arm access. High stability guarantees ... and cardiovascular procedures. An extension device ... can easily be attached for orthopedic ...
... The anatomy of the human body set ... new arcus-family. Thanks to the special concept of ... in all positions ergonomically adapts to the patient ... available when the C-arm is being utilised. The ...
Medicine Products: