( |pegol) 200mg & MTX | 4...)Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid,Arthritis,Health

| pegol) 200mg & MTX | 400mg & MTX |
|--------+-----------+--------------------+-------------------------|
| ACR 20 | 14 | 59* | 61* |
|--------+-----------+--------------------+-------------------------|
| ACR 50 | 8 | 37* | 40* |
|--------+-----------+--------------------+-------------------------|
| ACR 70 | 3 | 21* | 21* |
+-------------------------------------------------------------------+

* p<0.001

In the 24-week RAPID 2 trial, 634 patients were randomly allocated to receive one of three treatment regimens:
* 252 patients received 400 mg liquid CIMZIA(TM) at the start of the
study and at weeks two and four, then 200 mg given every two weeks,
together with methotrexate;
* 252 patients received 400 mg liquid CIMZIA(TM) every two weeks,
together with methotrexate;
* 130 patients received placebo every two weeks, together with
methotrexate.

In all three arms of the study the dose of methotrexate was 10mg per week or greater. Patients were assessed for improvement in signs and symptoms of RA. The primary endpoint for the study RAPID 2 was ACR20 responder rate at week 24.

24-Week ACR Responses for RAPID 2

+-------------------------------------------------------------------+
| | Placebo & | CIMZIA(TM) | CIMZIA(TM) |
| | MTX | (certolizumab pegol) | (certolizumab |
| | | 200mg & MTX | pegol) 400mg & MTX |
|--------+-----------+-------------------------+--------------------|
| ACR 20 | 9 | 57* | 58* |
|--------+-----------+-------------------------+--------------------|
| ACR 50 | 3 | 32
'"/>

Page: 1 2 3 4 5 6 7 8
Related medicine technology :

1. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
2. Eurands Zentase Effective in Treating Exocrine Pancreatic Insufficiency, Studies Show
3. Gabapentin Shown Effective for Fibromyalgia Pain
4. ApoCells Cancer Predictive Index Helps Oncologists Select the Most Effective Targeted Drug Therapy
5. Roxro Pharma’s Novel Intranasal Pain Reliever Effective, Well Tolerated in Phase 3 Study
6. XYOTAX More Cost Effective With Fewer Side Effects Than Gemcitabine or Vinorelbine in Treating Non-Small Cell Lung Cancer
7. Soliris Effective in PNH Patients With History of Aplastic Anemia and Myelodysplastic Syndromes
8. Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and Effective in Colorectal Cancer with Liver Metastases
9. Biotheras Imprime PGG Enhanced Effectiveness of Avastin in Cancer Study
10. Targanta Study Shows Oritavancin Treatment Effective in a Mouse Model of Anthrax
11. In New Study, Duloxetine Was Equally Effective, Regardless of Switch Method, in Reducing Painful Symptoms in Ssri Non- or Partial-responders with Depression